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Jim Souhan: Quarterback Sam Darnold lifts the Vikings again; his teammates return the favor

Burn Joins Moreau Redux “Eyes In the Trees”

Klaviyo, Inc. (NYSE:KVYO) Shares Sold by GSA Capital Partners LLPFormer Lincoln East, Nebraska wideout Malachi Coleman transfers to MinnesotaLANDOVER, Md. – Jimmy Carter was honored with a moment of silence before the Atlanta Falcons’ game at the Washington Commanders on Sunday night, hours after the 39th president of the United States died at the age of 100 in Plains, Georgia. Beyond being a Georgia native who led the country from the White House less than 8 miles (12 kilometers) away during his time in office from 1977-81, Carter was the first president to host the NFL's Super Bowl champions there when he welcomed the Pittsburgh Steelers in 1980. Recommended Videos Falcons owner Arthur Blank in a statement released by the team before kickoff said he was deeply saddened by the loss of his dear friend and mentor, calling Carter “a great American, a proud Georgian and an inspirational global humanitarian.” “He lived his life with great civic responsibility and took it upon himself to be the change he wished to see amongst other,” Blank said, recalling meeting Carter at The Home Depot. “President Carter’s kind and uniting spirit touched so many lives. He was a man of deep faith, and did everything with principal and grace, doing things the right way for the right reasons." ___ AP NFL: https://apnews.com/hub/nfl

Meeting Jimmy Carter — and getting a scoop about Bush, Blair and Iraq from the perfect gentlemanHyderabad: Traffic restrictions issued ahead of HCL CyclothonBus route diverted until December due to anti-social behaviour

CES 2025 Preview: TESSAN to Showcase Charging Solutions for Enhanced Connectivity and ConvenienceAvior Wealth Management LLC lessened its stake in Emerson Electric Co. ( NYSE:EMR – Free Report ) by 6.1% in the third quarter, according to the company in its most recent 13F filing with the Securities and Exchange Commission (SEC). The institutional investor owned 2,924 shares of the industrial products company’s stock after selling 189 shares during the period. Avior Wealth Management LLC’s holdings in Emerson Electric were worth $320,000 at the end of the most recent reporting period. Other hedge funds and other institutional investors have also bought and sold shares of the company. Capital Performance Advisors LLP purchased a new position in Emerson Electric in the 3rd quarter worth approximately $25,000. Transcendent Capital Group LLC purchased a new stake in shares of Emerson Electric in the 1st quarter valued at $31,000. Meeder Asset Management Inc. boosted its stake in shares of Emerson Electric by 361.5% in the 2nd quarter. Meeder Asset Management Inc. now owns 300 shares of the industrial products company’s stock valued at $33,000 after purchasing an additional 235 shares in the last quarter. Morton Brown Family Wealth LLC purchased a new stake in shares of Emerson Electric in the 3rd quarter valued at $33,000. Finally, Frazier Financial Advisors LLC purchased a new stake in shares of Emerson Electric in the 3rd quarter valued at $33,000. Hedge funds and other institutional investors own 74.30% of the company’s stock. Analyst Upgrades and Downgrades A number of equities research analysts recently commented on EMR shares. UBS Group assumed coverage on shares of Emerson Electric in a report on Wednesday, November 13th. They set a “neutral” rating and a $135.00 price target for the company. Robert W. Baird upped their target price on shares of Emerson Electric from $117.00 to $118.00 and gave the stock a “neutral” rating in a research report on Monday, November 4th. Deutsche Bank Aktiengesellschaft increased their price objective on shares of Emerson Electric from $136.00 to $140.00 and gave the company a “buy” rating in a research report on Wednesday, November 6th. Morgan Stanley assumed coverage on shares of Emerson Electric in a report on Friday, September 6th. They set an “underweight” rating and a $105.00 price target on the stock. Finally, KeyCorp raised their price target on shares of Emerson Electric from $125.00 to $140.00 and gave the company an “overweight” rating in a report on Wednesday, November 6th. One analyst has rated the stock with a sell rating, five have assigned a hold rating and thirteen have given a buy rating to the company. According to MarketBeat, Emerson Electric currently has an average rating of “Moderate Buy” and a consensus price target of $130.00. Emerson Electric Price Performance NYSE EMR opened at $130.07 on Friday. Emerson Electric Co. has a 12 month low of $87.55 and a 12 month high of $131.56. The stock has a market cap of $74.17 billion, a price-to-earnings ratio of 38.03, a PEG ratio of 2.17 and a beta of 1.30. The company’s 50 day moving average is $114.02 and its two-hundred day moving average is $110.74. The company has a current ratio of 1.77, a quick ratio of 1.40 and a debt-to-equity ratio of 0.26. Emerson Electric Increases Dividend The firm also recently declared a quarterly dividend, which will be paid on Tuesday, December 10th. Investors of record on Friday, November 15th will be issued a $0.5275 dividend. The ex-dividend date of this dividend is Friday, November 15th. This is a boost from Emerson Electric’s previous quarterly dividend of $0.53. This represents a $2.11 dividend on an annualized basis and a yield of 1.62%. Emerson Electric’s payout ratio is currently 61.70%. Insiders Place Their Bets In related news, SVP Michael H. Train sold 21,525 shares of the company’s stock in a transaction on Wednesday, November 6th. The shares were sold at an average price of $125.96, for a total transaction of $2,711,289.00. Following the completion of the transaction, the senior vice president now owns 262,408 shares in the company, valued at approximately $33,052,911.68. This represents a 7.58 % decrease in their ownership of the stock. The sale was disclosed in a legal filing with the Securities & Exchange Commission, which can be accessed through this hyperlink . 0.25% of the stock is currently owned by corporate insiders. Emerson Electric Company Profile ( Free Report ) Emerson Electric Co, a technology and software company, provides various solutions for customers in industrial, commercial, and consumer markets in the Americas, Asia, the Middle East, Africa, and Europe. It operates in six segments: Final Control, Control Systems & Software, Measurement & Analytical, AspenTech, Discrete Automation, and Safety & Productivity. Further Reading Receive News & Ratings for Emerson Electric Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Emerson Electric and related companies with MarketBeat.com's FREE daily email newsletter .

Meta is reportedly planning a significant upgrade for its Ray-Ban smart glasses, with the addition of built-in displays expected in a new version set to debut in 2025. According to a report by the Financial Times , these forthcoming glasses will feature a display designed to provide notifications and enable seamless interaction with Meta’s artificial intelligence (AI) technology. This development could mark a major step forward for the device, which has so far relied on audio-based features. Reportedly, the updated model aims to offer a more immersive, hands-free experience by expanding its capabilities beyond the existing voice assistant. While the report primarily highlights notifications and AI integration, it is likely the display could serve a broader range of functions, including navigation directions and enhanced phone or smartwatch notifications. The current generation of Ray-Ban smart glasses has been widely praised for blending advanced technology with the iconic Ray-Ban design. Equipped with a voice assistant, the glasses allow users to send messages, make calls, and perform other functions without lifting a finger. Built-in speakers deliver notifications and audio responses, eliminating the need for headphones. Connectivity is another strong point, as the glasses link to smartphones via Bluetooth. Some models are also equipped with a discreet camera for capturing photos and videos, and touch-sensitive controls on the frame make it easy to manage calls or media playback. Despite these features, the absence of a visual display has limited the glasses’ functionality compared to emerging competitors. Samsung and Google are reportedly working on their own smart glasses equipped with advanced AI-powered features, intensifying the competition in this space. With the upcoming third-generation model, Meta appears poised to maintain its competitive edge. The addition of a display is expected to significantly enhance user interaction, bridging the gap between fashion and functionality. The glasses will reportedly retain their sleek, classic look, ensuring that the technology remains unobtrusive and stylish.Google TV recently released a list of most-watched movies from 2024, Road House starring Jake Gyllenhaal, available on Prime Video, stands on the top. Some other notable inclusions are multiple Apple TV originals. Check out the other films on OTT that made it into the top 9 list of Google TV. Former UFC fighter Dalton accepts a bouncer position at a Florida Keys roadhouse, only to uncover the dark secrets lurking behind the paradise facade. OTT Platform: Amazon Prime Video P Diddy, the legendary rap mogul, is facing a wave of lawsuits and allegations. TMZ (a tabloid news organization) reveals the troubling details from those who had witnessed it firsthand. OTT Platform: Apple TV Solene, a 40-year-old single mom and Hayes Campbell, the lead singer of the August Moon boy band, find themselves in an unexpected romance. What follows is a series of chaos and misery. OTT Platform: Amazon Prime Video The Queen of Hearts takes over Auradon leading to chaos in the kingdom. Her rebellious daughter, Red, and Cinderella’s daughter, Chloe, travel in time together to stop the event that turned Red’s mother into a villain. OTT Platform: Disney+Hoststar Several generations after Caesar’s reign, apes become the dominant species, and humans have regressed into feral beings. Proximus Caesar who misinterprets the teachings of the legendary Caesar, enslaves other clans in a bid to unlock a mysterious vault, which has information about human technology. Noa, a young chimpanzee embarks on a journey to make everyone co-exist. OTT Platform: Disney+Hoststar Riley hits puberty, her emotions are in chaos with a new set of emotions coming to the headquarters! Joy, Sadness, Anger, Fear and Disgust, who have been taking care of Riley for the past 13 years, have become suppressed emotions. As Anxiety is taking over Railey’s personality, she tries to navigate challenges in a new environment. OTT Platform: Disney+Hoststar Bea is a 12-year-old who moves into her grandmother’s apartment in New York. A strange occurrence makes her see all the imaginary friends, who have been left behind as their real-life grown-ups. OTT Platform: Amazon Prime Video There you have it-dramas, heartwarming tales, adventures that hooked audiences in 2024. So, grab your popcorn and dive into the OTT platform – these top films on Google TV will be sure to keep you hooked! Also read- Streaming now: Check out 7 movies and web series hitting OTT today! Stay tuned to Yo! Vizag website and Instagram for more entertainment updates. Discussion about this post

Christmas Eve 72 years ago - simpler timesThe Golgi apparatus modifies, sorts and packages proteins to be sent to their final destinations, whether that's within or outside of the cell. It's a core function, but little studied in the setting of cancer immunology, especially when compared to other organelles like the mitochondria or endoplasmic reticulum. "So we were interested in looking a little bit more at the Golgi apparatus. It's obviously an important organelle. How is it being changed or what is its role in T-cells in terms of fighting cancer?" said Nathaniel Oberholtzer, an M.D./Ph.D. student who worked in the lab of Shikhar Mehrotra, Ph.D., co-leader of the Cancer Biology & Immunology Research Program at MUSC Hollings Cancer Center and scientific director of the Center for Cellular Therapy in the MUSC College of Medicine. As it turns out, the healthy function of the Golgi apparatus has a lot to do with how well T-cells function in killing cancer cells. Understanding how a signaling axis mitigates Golgi stress, enabling it to perform properly, points to a possible new therapeutic target for researchers to pursue to strengthen T-cells. Not only that, but Oberholtzer's research shows how the Golgi could be used as a biomarker to select the strongest T-cells for immunotherapy. Oberholtzer, as first author, and Mehrotra, as senior author, along with a team of Hollings scientists published the research this month in Science Advances . T-cells, part of the immune system, can kill cancer cells. CAR-T cells are T-cells that have been modified in the lab to home in on proteins on the surface of an individual's cancer cells . CAR-T cells are custom-made for each patient. Both T-cells and CAR-T cells can become "exhausted" in the hostile tumor microenvironment. Mehrotra's lab looks at ways to boost these cells so that they can fight cancer for a longer time. "The whole tumor microenvironment is conducive for the tumor itself, but not for the other cells which are trying to get in there," Mehrotra said. Just like people, cells are constantly subjected to stress—stress from biochemical reactions that have become unbalanced and mechanical stress from moving. Transient stress can be good. Stressing your muscles through exercise strengthens them, and transient stress on cells can prompt them to a response that ultimately strengthens them. "But if this stress stays there, which it does in the tumor microenvironment, the cells are just in continuous stress, and that will then lead to a very different phenotype and death," Mehrotra said. However, the researchers found that treating the Golgi apparatus with hydrogen sulfide created T-cells that could take more stress. "Hydrogen sulfide is a gaseous signaling molecule present in pretty much all mammalian cell types. Typically, it's a byproduct of different cellular processes, but it's actually been shown to have really important signaling roles as well," Oberholtzer said. "It can modify proteins through a process called sulfhydration, where it modifies cysteine residues and can change their activity." In this project, Oberholtzer found that this sulfhydration process, in modifying a protein called Prdx4 within the Golgi apparatus, confers protection in an oxidative setting. "When you have the stressors that the tumor microenvironment puts on T-cells, you get a disruption, or fragmentation, of the Golgi apparatus where it essentially isn't able to do its job. Hydrogen sulfide protects against that disruption," Oberholtzer said. Looking into this protective effect then led the researchers to look more closely at the Golgi apparatus by itself. "Essentially, if you just use the Golgi apparatus as a simple marker, if T-cells have a lot of Golgi versus less, the ones that have more Golgi are much more robust at killing tumor cells and controlling tumors," Oberholtzer explained. Using cell sorting technology at the Flow Cytometry & Cell Sorting Shared Resource at Hollings, the researchers sorted T-cells according to the amount of Golgi they contained. The top 30% were labeled Golgi-hi and the bottom 30% were labeled Golgi-lo. "Basically, all the cells which are expressing high Golgi have a very different phenotype. They are less exhausted, and they are much more potent in controlling tumors," Mehrotra said. This pre-clinical work suggests that sorting T-cells into Golgi-hi and Golgi-lo and reinfusing only the Golgi-hi cells into a patient would create a better chance of controlling the tumor . "Right now, we're working on doing some validation studies in the Center for Cellular Therapy to potentially be able to start a clinical trial to see if that has a translational ability as well," Oberholtzer said. More work is also needed to understand the role of Golgi stress when all of the organelles in a cell are under stress because of the tumor microenvironment . More information: Nathaniel Oberholtzer et al, H 2 S-Prdx4 axis mitigates Golgi stress to bolster tumor-reactive T cell immunotherapeutic response, Science Advances (2024). DOI: 10.1126/sciadv.adp1152

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