Current location: bet365 japan > bet365 quebec reddit > new york baccarat hotel > main body

new york baccarat hotel

2025-01-13 2025 European Cup new york baccarat hotel News
Daily Trading Desk: 2 trades for short-term gains; a large-cap defence PSU and a mid-cap IT solutions stock, both for 7% upmoveGal Gadot Reveals She Had a 'Massive Blood Clot' in Her Brain During Pregnancy: 'All I Wanted Was to Hold on and Live'new york baccarat hotel

TUNDE OYESINA writes that stakeholders in the justice sector have put forward divergent views on the strategy to be adopted in decongesting the apex court of the land Some stakeholders in the justice sector, including senior lawyers have expressed mixed feelings on how the decentralization of the Supreme Court could help in decongesting the apex court of too many cases. The arguments were sequel to a Bill seeking to decentralize the Supreme Court currently being considered at the House of Representatives. The Bill sponsored by Hon. Mansur Manu Soro, representing Darazo/Ganjuwa Federal Constituency, seeks to amend the Constitution to provide for the establishment of five divisions of the Supreme Court of Nigeria for timely dispensation of matters brought before the apex court. In his arguments, the lawmaker questioned the provisions of Section 230 of the 1999 Constitution that creates only one Supreme Court for the whole country without establishing divisions. He maintained that it is now time to establish divisions for the Supreme Court in the geo-political zones of the country to enhance access to the highest justice, minimize the logistical cost of accessing justice and ensure timely dispensation of matters brought before the apex court. The Bill has already scaled the first reading at the green chamber. Proponents of Supreme Court’s decentralization New Telegraph Law recalls that a retired Justice of the Abuja Division of the Court of Appeal, Justice Peter Ige, had during his valedictory session in 2023 called for the decentralization of the Supreme Court for more effective administration of justice. He said there was nothing wrong if the apex court has divisions in the nation’s six geopolitical zones like the appeal court. He added that decentralizing the Supreme Court would help to bring justice to the grass-roots. The retired jurist explained that the decentralization of the Supreme Court would reduce its burden and enable it to deliver justice without delays. In a similar vein, another retired Judge of the Court of Appeal, Justice Mudashiru Oniyangi had also in 2022 called for the decentralization of the Supreme Court to allow for speedy dispensation of justice in the country. Oniyangi who made this call during a valedictory session to mark his retirement from the Bench, submitted that the nation should consider establishing an appellate court in every state in the country to reduce the volume of pending cases. He said: “The Supreme Court has a number of cases but my question is why is the Supreme Court not decentralized in every geopolitical zone? The headquarter can be here in Abuja, as well as the Chief Justice of Nigeria. But, when that division is created, the Justices of the Supreme Court sent there will attend to matters in that geopolitical zone, but it will be the same one Supreme Court, no division.” “Abuja is full to the brim, cases are pending. The justices are trying, but the number of justices cannot cope with the pressure of jobs going on.” A Civil Rights Group, Justice and Transparency had also earlier this year called for the decentralization of the apex court. Speaking at a workshop, Executive Director of the Group, Henry Ikebuaku said: “We require an extreme decentralization of the entire criminal justice framework. This will empower states and surprisingly local communities to operate correctional centers to decrease the degree of dehumanization that inmates experience in our stuffed detention facilities. “The Supreme Court should be decentralized with the making of Supreme Courts at the six geopolitical zonal headquarters. The Court of Appeal has previously been decentralized, and the states have already been enabled to operate High Courts. “Establishment of Zonal Supreme Courts to treat specific classes of cases exception of those on fundamental human rights or constitutional rights of Nigerian citizens, is earnestly called for. Lawyers’ position In his comments, a rights activist, Onesimus Ruya, maintained that there cannot be more than one Supreme Court in the country because it’s the highest court in the land. Ruya said: “I think they should rather have more justices. There is no reason why we shouldn’t have up to 100 Supreme Court justices to reduce the workload. The only challenge they have is the workload. There are three courtrooms at the Supreme Court, most times only one is used. “The mover of the Bill is not looking at the real challenges, they are looking at politics. As we are now, we have courts of appeal in most of the geopolitical zones which will do the same work. Unless they are saying that those at the appeal court should end there, which gives litigants only one right of appeal which is not fair enough. “There would still be delays and also confusion or conflicting court decisions. I think what we need to decide and part of the restructuring process is the number of cases that get to the Supreme Court. There are too many of them that go to the Supreme Court on appeal”. Speaking in the same vein, a senior lawyer, Bright Enado, said decentralizing the Supreme Court will not reduce the delay of cases at the apex court. “A decentralized Supreme Court could only reduce the number of people going to Abuja for their cases for it would still be the same Supreme Court and the same number of people but now divided among the geopolitical zone. “We may have more Justices of the Supreme Court but I’m not too sure that it will reduce congestion. What can reduce congestion is to look internally at the kind of cases that find their way to the Supreme Court. That is the starting point, not every case should get there. It should be difficult to go to the Supreme Court. “People must learn to accept decisions of the appeal court and let it stop there. But, virtually every case that gets to the Court of Appeal gets to the Supreme Court and that is the problem. It’s not so much about the number of Supreme Courts that should be established. It should be on the number of cases that are allowed into the Supreme Court”. However, in his submissions, a senior lawyer, Edward Nwaogu, argued that decentralizing the apex court will improve the dispensation of justice. According to him, “Yes, if that would help us, we should amend the law and make the Supreme Court at Abuja the headquarters and make two to three zones. The Supreme Court too can have Divisions like the Court of appeal. We can then they find out how they can be managed together to streamline cases. “If they give conflicting judgements, there should be a process by which they streamline it. “The Court of Appeal that has Divisions has been able to manage the system in such a way that if they find conflicting judgement, they find a way of resolving it. If a Division in Enugu has given a decision that contradicts an earlier judgement of Lagos Division or whatever, you go to the whole process of which one to follow. “If the later judgement is seen to be given in ignorance of an earlier one, the law is quite clear that the law is given ‘per incuriam’. It denotes the idea that it is decided through inadvertence or ignorance of the relevant law. “The later judgement would bring in some other things that would have shown that this later one has overruled the earlier. So, the fear of conflicting judgement from different Divisions should not be a hindrance to it. “If decentralizing the Supreme Court will solve the problem of delay, it should be what we call reform”.

Four Canadian women honoured in World Rugby's Dream Teams of the Year MONACO — Canadians Alex Tessier, Sophie de Goede and Laetitia Royer have been named to World Rugby's Women’s 15s Dream Team of the Year. Canada sevens captain Olivia Apps, meanwhile, was selected to World Rugby's Women’s Sevens Dream Team. Canadian Press Nov 27, 2024 2:12 PM Nov 27, 2024 2:35 PM Share by Email Share on Facebook Share on X Share on LinkedIn Print Share via Text Message France's Marine Menager grabs Canada's Alex Tessier's leg as she runs the ball during WXV 1 women's rugby union action, in Vancouver on Sept. 29, 2024. THE CANADIAN PRESS/Ethan Cairns MONACO — Canadians Alex Tessier, Sophie de Goede and Laetitia Royer have been named to World Rugby's Women’s 15s Dream Team of the Year. Canada sevens captain Olivia Apps, meanwhile, was selected to World Rugby's Women’s Sevens Dream Team. The women's 15s world all-star squad also featured six players from top-ranked England and three from No. 2 New Zealand. The other three came from the U.S., Ireland and France. Tessier was also a finalist for the World Rugby Women’s 15s Player of the Year award won by England fullback Ellie Kildunne. France's Pauline Bourdon Sansus and England's Alex Matthews were the other finalists. Tessier won her 50th cap in 2024 and, playing at inside centre alongside fly half Claire Gallagher, led the Canada women to a historic first-ever victory over New Zealand to win the 2024 Pacific Four Series in May. The 22-19 comeback victory lifted Canada into second place in the women’s world rankings, its highest position since November 2016. Tessier's strong kicking game was also key for Canada. The 31-year-old from Sainte-Clotilde-de-Horton, Que., scored 27 points in starting all six matches for Canada in 2024 to up her career total to 48 points (including five tries) in 54 appearances. Tessier plays professionally in England for the Exeter Chiefs. De Goede made the all-star team despite tearing her anterior cruciate ligament in training in June. A finalist for the Women's Player of the Year award in 2022, the Victoria back-rower plays in England for Saracens. Royer, from Loretteville, Que., is a second-row forward who plays in France for ASM Romagnat. Top-ranked South Africa dominated the men's 15s all-star squad with seven players represented. Ireland had four players with New Zealand three and Argentina one. --- World Rugby's 15s Dream Teams of the Year Women 1. Hope Rogers (U.S.); 2. Georgia Ponsonby (New Zealand); 3. Maud Muir (England); 4. Zoe Aldcroft (England); 5. Laetitia Royer (Canada) ; 6. Aoife Wafer (Ireland)' 7. Sophie de Goede (Canada) ; 8. Alex Matthews (England); 9. Pauline Bourdon Sansus (France); 10. Holly Aitchison (England); 11. Katelyn Vahaakolo (New Zealand); 12. Alex Tessier (Canada) ; 13. Sylvia Brunt (New Zealand); 14. Abby Dow (England); 15. Ellie Kildunne (England). Men 1. Ox Nche (South Africa); 2. Malcolm Marx (South Africa); 3. Tyrel Lomax (New Zealand); 4. Eben Etzebeth (South Africa); 5. Tadhg Beirne (Ireland); 6. Pablo Matera (Argentina); 7. Pieter-Steph du Toit (South Africa); 8. Caelan Doris (Ireland); 9. Jamison Gibson-Park (Ireland); 10. Damian McKenzie (New Zealand); 11. James Lowe (Ireland); 12. Damian de Allende (South Africa); 13. Jesse Kriel (South Africa); 14. Cheslin Kolbe (South Africa); 15. Will Jordan (New Zealand). World Rugby Sevens Dreams Team of the Year Women Olivia Apps (Canada) , Michaela Blyde (New Zealand), Kristi Kirshe (U.S.), Maddison Levi (Australia), Ilona Maher (U.S.), Jorja Miller (New Zealand), Séraphine Okemba (France). Men Selvyn Davids (South Africa), Antoine Dupont (France), Aaron Grandidier Nkanang (France), Terry Kennedy (Ireland), Nathan Lawson (Australia), Ponipate Loganimasi (Fiji), Matías Osadczuk (Argentina). This report by The Canadian Press was first published Nov. 27, 2024. The Canadian Press See a typo/mistake? Have a story/tip? This has been shared 0 times 0 Shares Share by Email Share on Facebook Share on X Share on LinkedIn Print Share via Text Message More National Sports Hometown favourite Gushue beats Carruthers at Grand Slam's Kioti National Nov 27, 2024 2:13 PM Robert Wickens moving up to IMSA GTD series in 2025 thanks to new Bosch hand controls Nov 27, 2024 2:03 PM RCMP investigating death of Edmonton man after mixed martial arts fight Nov 27, 2024 1:14 PM Featured FlyerThe standard Lorem Ipsum passage, used since the 1500s "Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum." Section 1.10.32 of "de Finibus Bonorum et Malorum", written by Cicero in 45 BC "Sed ut perspiciatis unde omnis iste natus error sit voluptatem accusantium doloremque laudantium, totam rem aperiam, eaque ipsa quae ab illo inventore veritatis et quasi architecto beatae vitae dicta sunt explicabo. Nemo enim ipsam voluptatem quia voluptas sit aspernatur aut odit aut fugit, sed quia consequuntur magni dolores eos qui ratione voluptatem sequi nesciunt. Neque porro quisquam est, qui dolorem ipsum quia dolor sit amet, consectetur, adipisci velit, sed quia non numquam eius modi tempora incidunt ut labore et dolore magnam aliquam quaerat voluptatem. Ut enim ad minima veniam, quis nostrum exercitationem ullam corporis suscipit laboriosam, nisi ut aliquid ex ea commodi consequatur? Quis autem vel eum iure reprehenderit qui in ea voluptate velit esse quam nihil molestiae consequatur, vel illum qui dolorem eum fugiat quo voluptas nulla pariatur?" Thanks for your interest in Kalkine Media's content! To continue reading, please log in to your account or create your free account with us.

A Plant-Based Diet Can Transform Health for Smokers and Ex-Smokers, Say ExpertsNEW YORK — A number of President-elect Donald Trump 's most prominent Cabinet picks and appointees have been targeted by bomb threats and “swatting attacks," Trump's transition team said Wednesday. The FBI said it was investigating. “Last night and this morning, several of President Trump’s Cabinet nominees and Administration appointees were targeted in violent, unAmerican threats to their lives and those who live with them," Trump transition spokesperson Karoline Leavitt said in a statement. She said the attacks ranged from bomb threats to swatting, in which attackers initiate an emergency law enforcement response against a target victim under false pretenses. The tactic has become a popular one in recent years. President-elect Donald Trump arrives to speak at a meeting of the House GOP conference, followed by Rep. Elise Stefanik, R-N.Y., Wednesday, Nov. 13, 2024, in Washington. (AP Photo/Alex Brandon) “In response, law enforcement and other authorities acted quickly to ensure the safety of those who were targeted. President Trump and the entire Transition team are grateful for their swift action,” Leavitt said. Among those targeted were New York Rep. Elise Stefanik, Trump’s pick to serve as the next ambassador to the United Nations, Matt Gaetz, Trump’s initial pick to serve as attorney general, and former New York congressman Lee Zeldin, who has been tapped to lead the Environmental Protection Agency. Susie Wiles, Trump's incoming chief of staff, and Pam Bondi, the former Florida Attorney General whom Trump has chosen as Gaetz's replacement, were also targeted, according to a law enforcement official who spoke on condition of anonymity amid the ongoing investigation. Wiles and Bondi did not immediately respond to requests for comment. The FBI said in a statement that it was “aware of numerous bomb threats and swatting incidents targeting incoming administration nominees and appointees" and was "working with our law enforcement partners. We take all potential threats seriously, and as always, encourage members of the public to immediately report anything they consider suspicious to law enforcement.” Stefanik's office said that, on Wednesday morning, she, her husband, and their 3-year-old son were driving home from Washington for Thanksgiving when they were informed of a bomb threat to their residence in Saratoga County. Rep. Elise Stefanik, R-N.Y., is seated before President-elect Donald Trump arrives at a meeting of the House GOP conference, Wednesday, Nov. 13, 2024, in Washington. (AP Photo/Alex Brandon) "New York State, County law enforcement, and U.S. Capitol Police responded immediately with the highest levels of professionalism," her office said in a statement. “We are incredibly appreciative of the extraordinary dedication of law enforcement officers who keep our communities safe 24/7." The New York State Police said a team was dispatched to sweep Stefanik’s home on Wednesday morning in response to the bomb threat but did not locate any explosive devices. A spokesman for the agency directed further questions to the FBI. Zeldin said in a social media post that he and his family had been threatened. “A pipe bomb threat targeting me and my family at our home today was sent in with a pro-Palestinian themed message,” he wrote on X. “My family and I were not home at the time and are safe. We are working with law enforcement to learn more as this situation develops.” Police in Suffolk County, Long Island said emergency officers responded to a bomb threat Wednesday morning at an address listed in public records as Zeldin’s home and were checking the property. In Florida, meanwhile, the Okaloosa County sheriff’s office said in an advisory posted on Facebook that it “received notification of a bomb threat referencing former Congressman Matt Gaetz’s supposed mailbox at a home in the Niceville area around 9 a.m. this morning.” While a family member resides at the address, they said "former Congressman Gaetz is NOT a resident. The mailbox however was cleared and no devices were located. The immediate area was also searched with negative results.” Gaetz was Trump’s initial pick to serve as attorney general, but he withdrew from consideration amid allegations that he paid women for sex and slept with underage women. Gaetz has vehemently denied any wrongdoing and said last year that a Justice Department investigation into sex trafficking allegations involving underage girls had ended with no federal charges against him. The threats follow a political campaign marked by disturbing and unprecedented violence. In July, a gunman opened fire at a Trump rally in Butler, Pennsylvania, grazing the then-candidate in the ear with a bullet and killing one of his supporters. The U.S. Secret Service later thwarted a subsequent assassination attempt at Trump's West Palm Beach, Florida, golf course when an agent spotted the barrel of a gun poking through a perimeter fence while Trump was golfing. Public figures across the political spectrum have been targeted in recent years by hoax bomb threats and false reports of shootings at their homes. The judges overseeing the civil fraud case against Trump in New York and the criminal election interference case against him in Washington, D.C. were both targeted earlier this year. Justice Department special counsel Jack Smith, who recently abandoned the two criminal cases he brought against Trump, was also the subject of a fake emergency call on Christmas Day last year. Earlier this year, schools, government buildings and the homes of city officials in Springfield, Ohio received a string of hoax bomb threats after Trump falsely accused members of Springfield’s Haitian community of abducting and eating cats and dogs. And in 2022, a slew of historically Black colleges and universities nationwide were targeted with dozens of bomb threats with the vast majority arriving during the celebration of Black History Month. The U.S. Capitol Police said in a statement Wednesday that, “Anytime a Member of Congress is the victim of a 'swatting' incident, we work closely with our local and federal law enforcement partners. To protect ongoing investigations and to minimize the risk of copy-cats, we cannot provide more details at this time.” Republican House Speaker Mike Johnson called the threats “dangerous and unhinged.” “This year, there was not just one but TWO assassination attempts on President Trump. Now some of his Cabinet nominees and their families are facing bomb threats,” he wrote on X. “It is not who we are in America.” Among President-elect Donald Trump's picks are Susie Wiles for chief of staff, Florida Sen. Marco Rubio for secretary of state, former Democratic House member Tulsi Gabbard for director of national intelligence and Florida Rep. Matt Gaetz for attorney general. Susie Wiles, 67, was a senior adviser to Trump's 2024 presidential campaign and its de facto manager. Trump named Florida Sen. Marco Rubio to be secretary of state, making a former sharp critic his choice to be the new administration's top diplomat. Rubio, 53, is a noted hawk on China, Cuba and Iran, and was a finalist to be Trump's running mate on the Republican ticket last summer. Rubio is the vice chairman of the Senate Intelligence Committee and a member of the Senate Foreign Relations Committee. “He will be a strong Advocate for our Nation, a true friend to our Allies, and a fearless Warrior who will never back down to our adversaries,” Trump said of Rubio in a statement. The announcement punctuates the hard pivot Rubio has made with Trump, whom the senator called a “con man" during his unsuccessful campaign for the 2016 GOP presidential nomination. Their relationship improved dramatically while Trump was in the White House. And as Trump campaigned for the presidency a third time, Rubio cheered his proposals. For instance, Rubio, who more than a decade ago helped craft immigration legislation that included a path to citizenship for people in the U.S. illegally, now supports Trump's plan to use the U.S. military for mass deportations. Pete Hegseth, 44, is a co-host of Fox News Channel’s “Fox & Friends Weekend” and has been a contributor with the network since 2014, where he developed a friendship with Trump, who made regular appearances on the show. Hegseth lacks senior military or national security experience. If confirmed by the Senate, he would inherit the top job during a series of global crises — ranging from Russia’s war in Ukraine and the ongoing attacks in the Middle East by Iranian proxies to the push for a cease-fire between Israel, Hamas and Hezbollah and escalating worries about the growing alliance between Russia and North Korea. Hegseth is also the author of “The War on Warriors: Behind the Betrayal of the Men Who Keep Us Free,” published earlier this year. Trump tapped Pam Bondi, 59, to be attorney general after U.S. Rep. Matt Gaetz withdrew his name from consideration. She was Florida's first female attorney general, serving between 2011 and 2019. She also was on Trump’s legal team during his first impeachment trial in 2020. Considered a loyalist, she served as part of a Trump-allied outside group that helped lay the groundwork for his future administration called the America First Policy Institute. Bondi was among a group of Republicans who showed up to support Trump at his hush money criminal trial in New York that ended in May with a conviction on 34 felony counts. A fierce defender of Trump, she also frequently appears on Fox News and has been a critic of the criminal cases against him. Trump picked South Dakota Gov. Kristi Noem, a well-known conservative who faced sharp criticism for telling a story in her memoir about shooting a rambunctious dog, to lead an agency crucial to the president-elect’s hardline immigration agenda. Noem used her two terms leading a tiny state to vault to a prominent position in Republican politics. South Dakota is usually a political afterthought. But during the COVID-19 pandemic, Noem did not order restrictions that other states had issued and instead declared her state “open for business.” Trump held a fireworks rally at Mount Rushmore in July 2020 in one of the first large gatherings of the pandemic. She takes over a department with a sprawling mission. In addition to key immigration agencies, the Department of Homeland Security oversees natural disaster response, the U.S. Secret Service, and Transportation Security Administration agents who work at airports. The governor of North Dakota, who was once little-known outside his state, Burgum is a former Republican presidential primary contender who endorsed Trump, and spent months traveling to drum up support for him, after dropping out of the race. Burgum was a serious contender to be Trump’s vice presidential choice this summer. The two-term governor was seen as a possible pick because of his executive experience and business savvy. Burgum also has close ties to deep-pocketed energy industry CEOs. Trump made the announcement about Burgum joining his incoming administration while addressing a gala at his Mar-a-Lago club, and said a formal statement would be coming the following day. In comments to reporters before Trump took the stage, Burgum said that, in recent years, the power grid is deteriorating in many parts of the country, which he said could raise national security concerns but also drive up prices enough to increase inflation. “There's just a sense of urgency, and a sense of understanding in the Trump administration,” Burgum said. Robert F. Kennedy Jr. ran for president as a Democrat, than as an independent, and then endorsed Trump . He's the son of Democratic icon Robert Kennedy, who was assassinated during his own presidential campaign. The nomination of Kennedy to lead the Department of Health and Human Services alarmed people who are concerned about his record of spreading unfounded fears about vaccines . For example, he has long advanced the debunked idea that vaccines cause autism. Scott Bessent, 62, is a former George Soros money manager and an advocate for deficit reduction. He's the founder of hedge fund Key Square Capital Management, after having worked on-and-off for Soros Fund Management since 1991. If confirmed by the Senate, he would be the nation’s first openly gay treasury secretary. He told Bloomberg in August that he decided to join Trump’s campaign in part to attack the mounting U.S. national debt. That would include slashing government programs and other spending. “This election cycle is the last chance for the U.S. to grow our way out of this mountain of debt without becoming a sort of European-style socialist democracy,” he said then. Oregon Republican U.S. Rep. Lori Chavez-DeRemer narrowly lost her reelection bid this month, but received strong backing from union members in her district. As a potential labor secretary, she would oversee the Labor Department’s workforce, its budget and put forth priorities that impact workers’ wages, health and safety, ability to unionize, and employer’s rights to fire employers, among other responsibilities. Chavez-DeRemer is one of few House Republicans to endorse the “Protecting the Right to Organize” or PRO Act would allow more workers to conduct organizing campaigns and would add penalties for companies that violate workers’ rights. The act would also weaken “right-to-work” laws that allow employees in more than half the states to avoid participating in or paying dues to unions that represent workers at their places of employment. Scott Turner is a former NFL player and White House aide. He ran the White House Opportunity and Revitalization Council during Trump’s first term in office. Trump, in a statement, credited Turner, the highest-ranking Black person he’s yet selected for his administration, with “helping to lead an Unprecedented Effort that Transformed our Country’s most distressed communities.” Sean Duffy is a former House member from Wisconsin who was one of Trump's most visible defenders on cable news. Duffy served in the House for nearly nine years, sitting on the Financial Services Committee and chairing the subcommittee on insurance and housing. He left Congress in 2019 for a TV career and has been the host of “The Bottom Line” on Fox Business. Before entering politics, Duffy was a reality TV star on MTV, where he met his wife, “Fox and Friends Weekend” co-host Rachel Campos-Duffy. They have nine children. A campaign donor and CEO of Denver-based Liberty Energy, Write is a vocal advocate of oil and gas development, including fracking — a key pillar of Trump’s quest to achieve U.S. “energy dominance” in the global market. Wright also has been one of the industry’s loudest voices against efforts to fight climate change. He said the climate movement around the world is “collapsing under its own weight.” The Energy Department is responsible for advancing energy, environmental and nuclear security of the United States. Wright also won support from influential conservatives, including oil and gas tycoon Harold Hamm. Hamm, executive chairman of Oklahoma-based Continental Resources, a major shale oil company, is a longtime Trump supporter and adviser who played a key role on energy issues in Trump’s first term. President-elect Donald Trump tapped billionaire professional wrestling mogul Linda McMahon to be secretary of the Education Department, tasked with overseeing an agency Trump promised to dismantle. McMahon led the Small Business Administration during Trump’s initial term from 2017 to 2019 and twice ran unsuccessfully as a Republican for the U.S. Senate in Connecticut. She’s seen as a relative unknown in education circles, though she expressed support for charter schools and school choice. She served on the Connecticut Board of Education for a year starting in 2009 and has spent years on the board of trustees for Sacred Heart University in Connecticut. Brooke Rollins, who graduated from Texas A&M University with a degree in agricultural development, is a longtime Trump associate who served as White House domestic policy chief during his first presidency. The 52-year-old is president and CEO of the America First Policy Institute, a group helping to lay the groundwork for a second Trump administration. She previously served as an aide to former Texas Gov. Rick Perry and ran a think tank, the Texas Public Policy Foundation. Trump chose Howard Lutnick, head of brokerage and investment bank Cantor Fitzgerald and a cryptocurrency enthusiast, as his nominee for commerce secretary, a position in which he'd have a key role in carrying out Trump's plans to raise and enforce tariffs. Trump made the announcement Tuesday on his social media platform, Truth Social. Lutnick is a co-chair of Trump’s transition team, along with Linda McMahon, the former wrestling executive who previously led Trump’s Small Business Administration. Both are tasked with putting forward candidates for key roles in the next administration. The nomination would put Lutnick in charge of a sprawling Cabinet agency that is involved in funding new computer chip factories, imposing trade restrictions, releasing economic data and monitoring the weather. It is also a position in which connections to CEOs and the wider business community are crucial. Doug Collins is a former Republican congressman from Georgia who gained recognition for defending Trump during his first impeachment trial, which centered on U.S. assistance for Ukraine. Trump was impeached for urging Ukraine to investigate Joe Biden in 2019 during the Democratic presidential nomination, but he was acquitted by the Senate. Collins has also served in the armed forces himself and is currently a chaplain in the United States Air Force Reserve Command. "We must take care of our brave men and women in uniform, and Doug will be a great advocate for our Active Duty Servicemembers, Veterans, and Military Families to ensure they have the support they need," Trump said in a statement about nominating Collins to lead the Department of Veterans Affairs. Karoline Leavitt, 27, was Trump's campaign press secretary and currently a spokesperson for his transition. She would be the youngest White House press secretary in history. The White House press secretary typically serves as the public face of the administration and historically has held daily briefings for the press corps. Leavitt, a New Hampshire native, was a spokesperson for MAGA Inc., a super PAC supporting Trump, before joining his 2024 campaign. In 2022, she ran for Congress in New Hampshire, winning a 10-way Republican primary before losing to Democratic Rep. Chris Pappas. Leavitt worked in the White House press office during Trump's first term before she became communications director for New York Republican Rep. Elise Stefanik, Trump's choice for U.S. ambassador to the United Nations. Former Hawaii Rep. Tulsi Gabbard has been tapped by Trump to be director of national intelligence, keeping with the trend to stock his Cabinet with loyal personalities rather than veteran professionals in their requisite fields. Gabbard, 43, was a Democratic House member who unsuccessfully sought the party's 2020 presidential nomination before leaving the party in 2022. She endorsed Trump in August and campaigned often with him this fall. “I know Tulsi will bring the fearless spirit that has defined her illustrious career to our Intelligence Community,” Trump said in a statement. Gabbard, who has served in the Army National Guard for more than two decades, deploying to Iraq and Kuwait, would come to the role as somewhat of an outsider compared to her predecessor. The current director, Avril Haines, was confirmed by the Senate in 2021 following several years in a number of top national security and intelligence positions. Trump has picked John Ratcliffe, a former Texas congressman who served as director of national intelligence during his first administration, to be director of the Central Intelligence Agency in his next. Ratcliffe was director of national intelligence during the final year and a half of Trump's first term, leading the U.S. government's spy agencies during the coronavirus pandemic. “I look forward to John being the first person ever to serve in both of our Nation's highest Intelligence positions,” Trump said in a statement, calling him a “fearless fighter for the Constitutional Rights of all Americans” who would ensure “the Highest Levels of National Security, and PEACE THROUGH STRENGTH.” Trump has chosen former New York Rep. Lee Zeldin to serve as his pick to lead the Environmental Protection Agency . Zeldin does not appear to have any experience in environmental issues, but is a longtime supporter of the former president. The 44-year-old former U.S. House member from New York wrote on X , “We will restore US energy dominance, revitalize our auto industry to bring back American jobs, and make the US the global leader of AI.” “We will do so while protecting access to clean air and water,” he added. During his campaign, Trump often attacked the Biden administration's promotion of electric vehicles, and incorrectly referring to a tax credit for EV purchases as a government mandate. Trump also often told his audiences during the campaign his administration would “Drill, baby, drill,” referring to his support for expanded petroleum exploration. In a statement, Trump said Zeldin “will ensure fair and swift deregulatory decisions that will be enacted in a way to unleash the power of American businesses, while at the same time maintaining the highest environmental standards, including the cleanest air and water on the planet.” Trump has named Brendan Carr, the senior Republican on the Federal Communications Commission, as the new chairman of the agency tasked with regulating broadcasting, telecommunications and broadband. Carr is a longtime member of the commission and served previously as the FCC’s general counsel. He has been unanimously confirmed by the Senate three times and was nominated by both Trump and President Joe Biden to the commission. Carr made past appearances on “Fox News Channel," including when he decried Democratic Vice President Kamala Harris' pre-Election Day appearance on “Saturday Night Live.” He wrote an op-ed last month defending a satellite company owned by Trump supporter Elon Musk. Rep. Elise Stefanik is a representative from New York and one of Trump's staunchest defenders going back to his first impeachment. Elected to the House in 2014, Stefanik was selected by her GOP House colleagues as House Republican Conference chair in 2021, when former Wyoming Rep. Liz Cheney was removed from the post after publicly criticizing Trump for falsely claiming he won the 2020 election. Stefanik, 40, has served in that role ever since as the third-ranking member of House leadership. Stefanik’s questioning of university presidents over antisemitism on their campuses helped lead to two of those presidents resigning, further raising her national profile. If confirmed, she would represent American interests at the U.N. as Trump vows to end the war waged by Russia against Ukraine begun in 2022. He has also called for peace as Israel continues its offensive against Hamas in Gaza and its invasion of Lebanon to target Hezbollah. President-elect Donald Trump says he's chosen former acting Attorney General Matt Whitaker to serve as U.S. ambassador to NATO. Trump has expressed skepticism about the Western military alliance for years. Trump said in a statement Wednesday that Whitaker is “a strong warrior and loyal Patriot” who “will ensure the United States’ interests are advanced and defended” and “strengthen relationships with our NATO Allies, and stand firm in the face of threats to Peace and Stability.” The choice of Whitaker as the nation’s representative to the North Atlantic Treaty Organization is an unusual one, given his background is as a lawyer and not in foreign policy. A Republican congressman from Michigan who served from 1993 to 2011, Hoekstra was ambassador to the Netherlands during Trump's first term. “In my Second Term, Pete will help me once again put AMERICA FIRST,” Trump said in a statement announcing his choice. “He did an outstanding job as United States Ambassador to the Netherlands during our first four years, and I am confident that he will continue to represent our Country well in this new role.” Trump will nominate former Arkansas Gov. Mike Huckabee to be ambassador to Israel. Huckabee is a staunch defender of Israel and his intended nomination comes as Trump has promised to align U.S. foreign policy more closely with Israel's interests as it wages wars against the Iran-backed Hamas and Hezbollah. “He loves Israel, and likewise the people of Israel love him,” Trump said in a statement. “Mike will work tirelessly to bring about peace in the Middle East.” Huckabee, who ran unsuccessfully for the Republican presidential nomination in 2008 and 2016, has been a popular figure among evangelical Christian conservatives, many of whom support Israel due to Old Testament writings that Jews are God’s chosen people and that Israel is their rightful homeland. Trump has been praised by some in this important Republican voting bloc for moving the U.S. embassy in Israel from Tel Aviv to Jerusalem. Trump on Tuesday named real estate investor Steven Witkoff to be special envoy to the Middle East. The 67-year-old Witkoff is the president-elect's golf partner and was golfing with him at Trump's club in West Palm Beach, Florida, on Sept. 15, when the former president was the target of a second attempted assassination. Witkoff “is a Highly Respected Leader in Business and Philanthropy,” Trump said of Witkoff in a statement. “Steve will be an unrelenting Voice for PEACE, and make us all proud." Trump also named Witkoff co-chair, with former Georgia Sen. Kelly Loeffler, of his inaugural committee. Trump said Wednesday that he will nominate Gen. Keith Kellogg to serve as assistant to the president and special envoy for Ukraine and Russia. Kellogg, a retired Army lieutenant general who has long been Trump’s top adviser on defense issues, served as National Security Advisor to Trump's former Vice President Mike Pence. For the America First Policy Institute, one of several groups formed after Trump left office to help lay the groundwork for the next Republican administration, Kellogg in April wrote that “bringing the Russia-Ukraine war to a close will require strong, America First leadership to deliver a peace deal and immediately end the hostilities between the two warring parties.” (AP Photo/Mariam Zuhaib) Trump asked Rep. Michael Waltz, R-Fla., a retired Army National Guard officer and war veteran, to be his national security adviser, Trump announced in a statement Tuesday. The move puts Waltz in the middle of national security crises, ranging from efforts to provide weapons to Ukraine and worries about the growing alliance between Russia and North Korea to the persistent attacks in the Middle East by Iran proxies and the push for a cease-fire between Israel and Hamas and Hezbollah. “Mike has been a strong champion of my America First Foreign Policy agenda,” Trump's statement said, "and will be a tremendous champion of our pursuit of Peace through Strength!” Waltz is a three-term GOP congressman from east-central Florida. He served multiple tours in Afghanistan and also worked in the Pentagon as a policy adviser when Donald Rumsfeld and Robert Gates were defense chiefs. He is considered hawkish on China, and called for a U.S. boycott of the 2022 Winter Olympics in Beijing due to its involvement in the origin of COVID-19 and its mistreatment of the minority Muslim Uighur population. Stephen Miller, an immigration hardliner , was a vocal spokesperson during the presidential campaign for Trump's priority of mass deportations. The 39-year-old was a senior adviser during Trump's first administration. Miller has been a central figure in some of Trump's policy decisions, notably his move to separate thousands of immigrant families. Trump argued throughout the campaign that the nation's economic, national security and social priorities could be met by deporting people who are in the United States illegally. Since Trump left office in 2021, Miller has served as the president of America First Legal, an organization made up of former Trump advisers aimed at challenging the Biden administration, media companies, universities and others over issues such as free speech and national security. Thomas Homan, 62, has been tasked with Trump’s top priority of carrying out the largest deportation operation in the nation’s history. Homan, who served under Trump in his first administration leading U.S. Immigration and Customs Enforcement, was widely expected to be offered a position related to the border, an issue Trump made central to his campaign. Though Homan has insisted such a massive undertaking would be humane, he has long been a loyal supporter of Trump's policy proposals, suggesting at a July conference in Washington that he would be willing to "run the biggest deportation operation this country’s ever seen.” Democrats have criticized Homan for his defending Trump's “zero tolerance” policy on border crossings during his first administration, which led to the separation of thousands of parents and children seeking asylum at the border. Dr. Mehmet Oz, 64, is a former heart surgeon who hosted “The Dr. Oz Show,” a long-running daytime television talk show. He ran unsuccessfully for the U.S. Senate as the Republican nominee in 2022 and is an outspoken supporter of Trump, who endorsed Oz's bid for elected office. Elon Musk, left, and Vivek Ramaswamy speak before Republican presidential nominee former President Donald Trump at an Oct. 27 campaign rally at Madison Square Garden in New York. Trump on Tuesday said Musk and former Republican presidential candidate Ramaswamy will lead a new “Department of Government Efficiency" — which is not, despite the name, a government agency. The acronym “DOGE” is a nod to Musk's favorite cryptocurrency, dogecoin. Trump said Musk and Ramaswamy will work from outside the government to offer the White House “advice and guidance” and will partner with the Office of Management and Budget to “drive large scale structural reform, and create an entrepreneurial approach to Government never seen before.” He added the move would shock government systems. It's not clear how the organization will operate. Musk, owner of X and CEO of Tesla and SpaceX, has been a constant presence at Mar-a-Lago since Trump won the presidential election. Ramaswamy suspended his campaign in January and threw his support behind Trump. Trump said the two will “pave the way for my Administration to dismantle Government Bureaucracy, slash excess regulations, cut wasteful expenditures, and restructure Federal Agencies.” Russell Vought held the position during Trump’s first presidency. After Trump’s initial term ended, Vought founded the Center for Renewing America, a think tank that describes its mission as “renew a consensus of America as a nation under God.” Vought was closely involved with Project 2025, a conservative blueprint for Trump’s second term that he tried to distance himself from during the campaign. Vought has also previously worked as the executive and budget director for the Republican Study Committee, a caucus for conservative House Republicans. He also worked at Heritage Action, the political group tied to The Heritage Foundation, a conservative think tank. Dan Scavino, deputy chief of staff Scavino, whom Trump's transition referred to in a statement as one of “Trump's longest serving and most trusted aides,” was a senior adviser to Trump's 2024 campaign, as well as his 2016 and 2020 campaigns. He will be deputy chief of staff and assistant to the president. Scavino had run Trump's social media profile in the White House during his first administration. He was also held in contempt of Congress in 2022 after a month-long refusal to comply with a subpoena from the House committee’s investigation into the Jan. 6, 2021, attack on the U.S. Capitol. James Blair, deputy chief of staff Blair was political director for Trump's 2024 campaign and for the Republican National Committee. He will be deputy chief of staff for legislative, political and public affairs and assistant to the president. Blair was key to Trump's economic messaging during his winning White House comeback campaign this year, a driving force behind the candidate's “Trump can fix it” slogan and his query to audiences this fall if they were better off than four years ago. Taylor Budowich, deputy chief of staff Budowich is a veteran Trump campaign aide who launched and directed Make America Great Again, Inc., a super PAC that supported Trump's 2024 campaign. He will be deputy chief of staff for communications and personnel and assistant to the president. Budowich also had served as a spokesman for Trump after his presidency. William McGinley, White House counsel McGinley was White House Cabinet secretary during Trump's first administration, and was outside legal counsel for the Republican National Committee's election integrity effort during the 2024 campaign. In a statement, Trump called McGinley “a smart and tenacious lawyer who will help me advance our America First agenda, while fighting for election integrity and against the weaponization of law enforcement.” Jay Bhattacharya, National Institutes of Health Trump has chosen Dr. Jay Bhattacharya to lead the National Institutes of Health. Bhattacharya is a physician and professor at Stanford University School of Medicine, and is a critic of pandemic lockdowns and vaccine mandates. He promoted the idea of herd immunity during the pandemic, arguing that people at low risk should live normally while building up immunity to COVID-19 through infection. The National Institutes of Health funds medical research through competitive grants to researchers at institutions throughout the nation. NIH also conducts its own research with thousands of scientists working at its labs in Bethesda, Maryland. Jamieson Greer, U.S. trade representative Kevin Hassett, Director of the White House National Economic Council Trump is turning to two officials with experience navigating not only Washington but the key issues of income taxes and tariffs as he fills out his economic team. He announced he has chosen international trade attorney Jamieson Greer to be his U.S. trade representative and Kevin Hassett as director of the White House National Economic Council. While Trump has in several cases nominated outsiders to key posts, these picks reflect a recognition that his reputation will likely hinge on restoring the public’s confidence in the economy. Trump said in a statement that Greer was instrumental in his first term in imposing tariffs on China and others and replacing the trade agreement with Canada and Mexico, “therefore making it much better for American Workers.” Hassett, 62, served in the first Trump term as chairman of the Council of Economic Advisers. He has a doctorate from the University of Pennsylvania and worked at the right-leaning American Enterprise Institute before joining the Trump White House in 2017. Associated Press writers Alanna Durkin Richer, Colleen Long and Eric Tucker in Washington and Anthony Izaguirre in Albany, New York contributed to this report. Respond: Write a letter to the editor | Write a guest opinion Subscribe to stay connected to Tucson. A subscription helps you access more of the local stories that keep you connected to the community. Get Government & Politics updates in your inbox! Stay up-to-date on the latest in local and national government and political topics with our newsletter.

Biden calls for Assad to be 'held accountable'NEW YORK — Oliver Bjorkstrand had two goals and two assists to help Philipp Grubauer and the Seattle Kraken beat the New York Rangers 7-5 on Sunday. Eeli Tolvanen had a goal and two assists for Seattle, which trailed 3-1 early in the second period. Brandon Tanev, Vince Dunn, Shane Wright and Yanni Gourde also scored, and Grubauer made 32 saves. K'Andre Miller and Vincent Trocheck each had a goal and an assist for New York, which lost for the seventh time in nine games. Reilly Smith, Filip Chytil and Alexis Lafreniere also scored. The Rangers traded captain Jacob Trouba to Anaheim on Friday, and then topped Pittsburgh for a 4-2 victory. Jonathan Quick made 15 saves for New York while subbing for Igor Shesterkin, who was away from the team because his wife went into labor with their second child. Shesterkin's eight-year contract extension was announced Saturday. Wright's seventh goal of the season gave Seattle a 6-3 lead 11:13 into the third period. But New York pulled within one on goals by Miller and Lafreniere. Gourde's empty-netter at 18:14 helped close it out for the Kraken. Takeaways Rangers: Allowed six or more goals for the third time in their last eight home games. Kraken: Grubauer won for only the second time in 10 decisions. Key moment Tolvanen's tying goal 88 seconds after Tanev cut Seattle's deficit to one energized the Kraken in the second period. Key stat The Rangers fell to 7-6-1 at home with a third loss in their last five games at Madison Square Garden. Up next The Kraken host the Florida Panthers on Tuesday. The Rangers host the Chicago Blackhawks on Monday.

Trump Cabinet picks, appointees targeted by bomb threats and swatting attacksSEOUL, South Korea — A jetliner skidded off a runway, slammed into a concrete fence and burst into flames Sunday in South Korea after its landing gear apparently failed to deploy. All but two of the 181 people aboard were killed in one of the country’s worst aviation disasters , officials said. The Boeing 737-800 operated by Jeju Air plane arrived from Bangkok and crashed while attempting to land in the town of Muan, about 180 miles south of Seoul. Footage of the crash aired by South Korean television showed the plane skidding across the airstrip at high speed, evidently with its landing gear still closed, and slamming into the wall, triggering an explosion and generating plumes of thick, black smoke. The crash killed 179 people, the South Korean fire agency said. Emergency workers pulled two crew members to safety. They were conscious and did not appear to have any life-threatening injuries, health officials said. The chief of the Muan fire station, Lee Jeong-hyeon, told a televised briefing that the plane was completely destroyed, with only the tail assembly still recognizable in the wreckage. Officials were investigating the cause of the crash, including whether the aircraft was struck by birds, Lee said. The control tower issued a warning about birds to the plane shortly before it intended to land and gave the crew permission to land in a different area, Transport Ministry officials said. The crew sent out a distress signal shortly before the crash, officials said. Investigators retrieved the jet's flight data and cockpit voice recorders, said senior Transport Ministry official Joo Jong-wan. He said it may take months to complete the probe into the crash. The runway will be closed until Jan. 1, the ministry said. Video of the crash indicated that the pilots did not deploy flaps or slats to slow the aircraft, suggesting a possible hydraulic failure, and they did not manually lower the landing gear, suggesting they did not have time, said John Cox, a retired airline pilot and CEO of Safety Operating Systems in St. Petersburg, Florida. Despite that, the jetliner was under control and traveling in a straight line, and damage and injuries likely would have been minimized if not for a barrier being so close to the runway, Cox said. “It’s all in one piece. Everything is coming along fine until it hits that wall, at which point it disintegrates into a catastrophe,” he said. Another aviation expert said videos showed the aircraft had used up much of the runway before touching down. With little braking ability, the aircraft skidded atop its engine cowlings, said Ross “Rusty” Aimer, CEO of Aero Consulting Experts. “It's basically like skidding on ice,” he said. The Boeing 737-800 is a "proven airplane" that belongs to a different class of aircraft than the Boeing 737 Max jetliner that was linked to fatal crashes in 2018 and 2019, added Alan Price, a former chief pilot at Delta Air Lines and now a consultant. More than 4,500 of the planes are in service around the world, according to the aviation analytics company Cirium. One of the survivors was being treated for fractures to his ribs, shoulder blade and upper spine, said Ju Woong, director of the Ewha Womans University Seoul Hospital. Ju said the man, whose name was not released, told doctors he “woke up to find (himself) rescued.” Details on the other survivor were not immediately available. The passengers were predominantly South Korean and included two people from Thailand. Officials identified 88 of them in the hours after the crash, the fire agency said. Thailand’s prime minister, Paetongtarn Shinawatra, expressed condolences to the families of those aboard the plane in a post on X. Paetongtarn said she ordered the Ministry of Foreign Affairs to provide assistance. Boonchuay Duangmanee, the father of a Thai passenger, told The Associated Press that his daughter, Jongluk, had been working in a factory in South Korea for several years and returned to Thailand to visit her family. "I never thought that this would be the last time we would see each other forever,” he said. Kerati Kijmanawat, the director of Thailand's airports, confirmed in a statement that Jeju Air flight 7C 2216 departed from Bangkok's Suvarnabhumi Airport with no reports of anything abnormal aboard the aircraft or on the runway. Jeju Air in a statement expressed its “deep apology” over the crash and said it will do its “utmost to manage the aftermath of the accident.” In a televised news conference, the company's president, Kim E-bae, bowed deeply with other senior company officials as he apologized to bereaved families and said he feels “full responsibility” for the crash. He said the company had not identified any mechanical problems with the aircraft following regular checkups and that he would wait for the results of government investigations. Family members wailed as officials announced the names of some victims at a lounge in the Muan airport. Boeing said in a statement on X that it was in contact with Jeju Air and was ready to support the company in dealing with the crash. The crash happened as South Korea is embroiled in a political crisis triggered by President Yoon Suk Yeol’s stunning imposition of martial law and ensuing impeachment . South Korean lawmakers on Friday impeached acting President Han Duck-soo and suspended his duties, leading Deputy Prime Minister Choi Sang-mok to take over. Choi, who traveled to the site in Muan, called for officials to use all available resources to identify the dead as soon as possible. The government declared Muan a special disaster zone and designated a weeklong national mourning period. Yoon’s office said his chief secretary, Chung Jin-suk, presided over an emergency meeting between senior presidential staff to discuss the crash and reported the details to Choi. Yoon expressed condolences to the victims in a Facebook post. In Rome’s St. Peter’s Square, Pope Francis said he joined in “prayer for the survivors and the dead.” U.S. President Joe Biden said the United States was ready to offer “any necessary assistance.” The Muan crash is one of the deadliest disasters in South Korea’s aviation history. The last time South Korea suffered a large-scale air disaster was in 1997, when a Korean Airlines plane crashed in Guam, killing 228 people on board. In 2013, an Asiana Airlines plane crash-landed in San Francisco, killing three and injuring about 200. Sunday’s accident was also one of the worst landing disasters since a July 2007 crash that killed all 187 people on board and 12 others on the ground when an Airbus A320 slid off a slick airstrip in Sao Paulo, Brazil, and hit a nearby building, according to data compiled by the Flight Safety Foundation, a nonprofit group aimed at improving air safety. In 2010, 158 people died when an Air India Express aircraft overshot a runway in Mangalore, India, and plummeted into a gorge before erupting into flames, according to the safety foundation.

Stock Radar: ITC takes support above 200-DMA after falling by about 10% from highs; time to buy?BOSTON--(BUSINESS WIRE)--Dec 8, 2024-- Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) today announced longer-term data for CASGEVYTM (exagamglogene autotemcel) from global clinical trials in people with severe sickle cell disease (SCD) or transfusion-dependent beta thalassemia (TDT). CASGEVY is the first and only approved CRISPR/Cas9 gene-edited therapy. The results, presented at the American Society of Hematology (ASH) Annual Meeting and Exposition, continue to demonstrate the transformative, durable clinical benefits of CASGEVY. The longest follow up for both SCD and TDT patients now extends more than 5 years, with a median of 33.2 months and 38.1 months, respectively. “These comprehensive data provide additional evidence of the benefits of eradicating transfusion requirements for people with transfusion-dependent beta thalassemia and vaso-occlusive crises for those with sickle cell disease,” said Franco Locatelli, M.D., Ph.D., Professor of Pediatrics at the Catholic University of the Sacred Heart of Rome, Director of the Department of Pediatric Hematology and Oncology at Bambino Gesù Children’s Hospital, Chair of Vertex’s TDT Program Steering Committee, and Presenting Author of the CASGEVY clinical data at ASH. “With median follow-up around three years there is strong evidence for the durability of these beneficial effects following treatment with CASGEVY.” “CASGEVY is changing the outlook for people living with sickle cell disease and beta thalassemia, with these data reinforcing the immense clinical value a durable one-time therapy can provide to patients,” said Carmen Bozic, M.D., Executive Vice President, Global Medicines Development and Medical Affairs, and Chief Medical Officer at Vertex. “We have a strong commitment to build on our progress in bringing CASGEVY to patients around the world.” New long-term follow-up data presented from the CASGEVY trials Vertex had seven abstracts accepted at the ASH annual meeting as outlined below: Progress in bringing CASGEVY to patients around the world CASGEVY is approved for both SCD and TDT in the U.S., the European Union, Great Britain, Canada, Switzerland, Bahrain and the Kingdom of Saudi Arabia, and Vertex plans to make submissions in the United Arab Emirates and Kuwait. More than 45 authorized treatment centers have been activated globally to support the delivery of CASGEVY, and more than 40 patients have had a first cell collection. Vertex is continuing to work with reimbursement authorities to secure sustainable access for patients. Through this work, Vertex has agreements to provide CASGEVY in multiple countries, including the U.S., England (TDT), Austria, Bahrain and the Kingdom of Saudi Arabia, and continues to make strong progress in others, including positive Health Technology Assessments (HTAs) in Canada for both diseases and advancing access negotiations for SCD patients in England. In the U.S., Vertex recently secured an industry-first, voluntary agreement with the Centers for Medicare & Medicaid Services (CMS) on a single outcomes-based arrangement available to all state Medicaid programs to ensure broad and equitable access to CASGEVY. To support this progress on patient access and growing patient demand, Vertex has received approval for a third manufacturing facility for CASGEVY with our partner Lonza. About Sickle Cell Disease (SCD) SCD is a debilitating, progressive and life-shortening disease. SCD patients report health-related quality of life scores well below the general population, and the lifetime health care costs in the U.S. of managing SCD for patients with recurrent VOCs is estimated between $4 and $6 million. SCD is an inherited blood disorder that affects the red blood cells, which are essential for carrying oxygen to all organs and tissues of the body. SCD causes severe pain, organ damage and shortened life span due to misshapen or “sickled” red blood cells. The clinical hallmark of SCD is VOCs, which are caused by blockages of blood vessels by sickled red blood cells and result in severe and debilitating pain that can happen anywhere in the body at any time. SCD requires a lifetime of treatment and results in a reduced life expectancy. In the U.S., the median age of death for patients living with SCD is approximately 45 years. A cure for SCD today is a stem cell transplant from a matched donor, but this option is only available to a small fraction of patients living with SCD because of the lack of available donors. About Transfusion-Dependent Beta Thalassemia (TDT) TDT is a serious, life-threatening genetic disease. TDT patients report health-related quality of life scores below the general population and the lifetime health care costs in the U.S. of managing TDT are estimated between $5 and $5.7 million. TDT requires frequent blood transfusions and iron chelation therapy throughout a person’s life. Due to anemia, patients living with TDT may experience fatigue and shortness of breath, and infants may develop failure to thrive, jaundice and feeding problems. Complications of TDT can also include an enlarged spleen, liver and/or heart, misshapen bones and delayed puberty. TDT requires lifelong treatment and significant use of health care resources, and ultimately results in reduced life expectancy, decreased quality of life and reduced lifetime earnings and productivity. In the U.S., the median age of death for patients living with TDT is 37 years. Stem cell transplant from a matched donor is a curative option but is only available to a small fraction of people living with TDT because of the lack of available donors. About CASGEVYTM (exagamglogene autotemcel [exa-cel]) CASGEVYTM is a non-viral, ex vivo CRISPR/Cas9 gene-edited cell therapy for eligible patients with SCD or TDT, in which a patient’s own hematopoietic stem and progenitor cells are edited at the erythroid specific enhancer region of the BCL11A gene through a precise double-strand break. This edit results in the production of high levels of fetal hemoglobin (HbF; hemoglobin F) in red blood cells. HbF is the form of the oxygen-carrying hemoglobin that is naturally present during fetal development, which then switches to the adult form of hemoglobin after birth. CASGEVY has been shown to reduce or eliminate VOCs for patients with SCD and transfusion requirements for patients with TDT. CASGEVY is approved for eligible SCD and TDT patients 12 years and older by multiple regulatory bodies around the world. About the CLIMB Trials The ongoing Phase 1/2/3 open-label trials, CLIMB-111 and CLIMB-121, are designed to assess the safety and efficacy of a single dose of CASGEVY in patients ages 12 to 35 years with TDT or with SCD and recurrent VOCs. The trials are closed for enrollment. Patients will be followed for approximately two years after CASGEVY infusion in these trials. Each patient will be asked to participate in the ongoing long-term, open-label trial, CLIMB-131. CLIMB-131 is designed to evaluate the long-term safety and efficacy of CASGEVY in patients who received CASGEVY, including those in other CLIMB trials. The trial is designed to follow patients for up to 15 years after CASGEVY infusion. U.S. INDICATIONS AND IMPORTANT SAFETY INFORMATION FOR CASGEVY (exagamglogene autotemcel) WHAT IS CASGEVY? CASGEVY is a one-time therapy used to treat people aged 12 years and older with: • sickle cell disease (SCD) who have frequent vaso-occlusive crises or VOCs • beta thalassemia (β-thalassemia) who need regular blood transfusions CASGEVY is made specifically for each patient, using the patient’s own edited blood stem cells, and increases the production of a special type of hemoglobin called hemoglobin F (fetal hemoglobin or HbF). Having more HbF increases overall hemoglobin levels and has been shown to improve the production and function of red blood cells. This can eliminate VOCs in people with sickle cell disease and eliminate the need for regular blood transfusions in people with beta thalassemia. IMPORTANT SAFETY INFORMATION What is the most important information I should know about CASGEVY? After treatment with CASGEVY, you will have fewer blood cells for a while until CASGEVY takes hold (engrafts) into your bone marrow. This includes low levels of platelets (cells that usually help the blood to clot) and white blood cells (cells that usually fight infections). Your doctor will monitor this and give you treatment as required. The doctor will tell you when blood cell levels return to safe levels. You may experience side effects associated with other medicines administered as part of the treatment regimen for CASGEVY. Talk to your physician regarding those possible side effects. Your healthcare provider may give you other medicines to treat your side effects. How will I receive CASGEVY? Your healthcare provider will give you other medicines, including a conditioning medicine, as part of your treatment with CASGEVY. It’s important to talk to your healthcare provider about the risks and benefits of all medicines involved in your treatment. After receiving the conditioning medicine, it may not be possible for you to become pregnant or father a child. You should discuss options for fertility preservation with your healthcare provider before treatment. STEP 1: Before CASGEVY treatment, a doctor will give you mobilization medicine(s). This medicine moves blood stem cells from your bone marrow into the blood stream. The blood stem cells are then collected in a machine that separates the different blood cells (this is called apheresis). This entire process may happen more than once. Each time, it can take up to one week. During this step rescue cells are also collected and stored at the hospital. These are your existing blood stem cells and are kept untreated just in case there is a problem in the treatment process. If CASGEVY cannot be given after the conditioning medicine, or if the modified blood stem cells do not take hold (engraft) in the body, these rescue cells will be given back to you. If you are given rescue cells, you will not have any treatment benefit from CASGEVY. STEP 2: After they are collected, your blood stem cells will be sent to the manufacturing site where they are used to make CASGEVY. It may take up to 6 months from the time your cells are collected to manufacture and test CASGEVY before it is sent back to your healthcare provider. STEP 3: Shortly before your stem cell transplant, your healthcare provider will give you a conditioning medicine for a few days in hospital. This will prepare you for treatment by clearing cells from the bone marrow, so they can be replaced with the modified cells in CASGEVY. After you are given this medicine, your blood cell levels will fall to very low levels. You will stay in the hospital for this step and remain in the hospital until after the infusion with CASGEVY. STEP 4: One or more vials of CASGEVY will be given into a vein (intravenous infusion) over a short period of time. After the CASGEVY infusion, you will stay in hospital so that your healthcare provider can closely monitor your recovery. This can take 4-6 weeks, but times can vary. Your healthcare provider will decide when you can go home. What should I avoid after receiving CASGEVY? What are the possible or reasonably likely side effects of CASGEVY? The most common side effects of CASGEVY include: Your healthcare provider will test your blood to check for low levels of blood cells (including platelets and white blood cells). Tell your healthcare provider right away if you get any of the following symptoms: These are not all the possible side effects of CASGEVY. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. General information about the safe and effective use of CASGEVY Talk to your healthcare provider about any health concerns. Please see full Prescribing Information including Patient Information for CASGEVY. About Vertex Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including acute and neuropathic pain, APOL1-mediated kidney disease, IgA nephropathy, primary membranous nephropathy, autosomal dominant polycystic kidney disease, type 1 diabetes and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 15 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn , Facebook , Instagram , YouTube and X . (VRTX-GEN) Vertex Special Note Regarding Forward-Looking Statements This press release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, the statements by Franco Locatelli, M.D., Ph.D. and Carmen Bozic, M.D., in this press release, and statements regarding expectations for the anticipated transformative, durable clinical benefits of CASGEVY, plans to continue working with reimbursement authorities to secure sustainable access for patients, including our expectations for progress in Canada and England, and our plans for and design of the CLIMB studies. While we believe the forward-looking statements contained in this press release are accurate, these forward-looking statements represent the company's beliefs only as of the date of this press release and there are a number of risks and uncertainties that could cause actual events or results to differ materially from those expressed or implied by such forward-looking statements. Those risks and uncertainties include, among other things, that eligible patient access to CASGEVY may not be achieved on the anticipated timeline, or at all, that data from the company's development programs may not support registration or further development of its compounds due to safety, efficacy, and other reasons, and other risks listed under the heading “Risk Factors” in Vertex's most recent annual report and subsequent quarterly reports filed with the Securities and Exchange Commission at www.sec.gov and available through the company's website at www.vrtx.com . You should not place undue reliance on these statements, or the scientific data presented. Vertex disclaims any obligation to update the information contained in this press release as new information becomes available. View source version on businesswire.com : https://www.businesswire.com/news/home/20241206536804/en/ CONTACT: Vertex Pharmaceuticals Incorporated Investors: InvestorInfo@vrtx.comMedia : mediainfo@vrtx.com or International: +44 20 3204 5275 or U.S.: 617-341-6992 or Heather Nichols: +1 617-839-3607 KEYWORD: MASSACHUSETTS EUROPE UNITED STATES NORTH AMERICA INDUSTRY KEYWORD: BIOTECHNOLOGY PHARMACEUTICAL HEALTH CLINICAL TRIALS SOURCE: Vertex Pharmaceuticals Incorporated Copyright Business Wire 2024. PUB: 12/08/2024 12:52 PM/DISC: 12/08/2024 12:50 PM http://www.businesswire.com/news/home/20241206536804/enNone

Matt Gaetz selling $500 Cameo videos after withdrawing from AG bidTop 25 roundup: No. 14 Oklahoma cruises, improves to 12-0

Edifier continues to establish its reputation as a premier audio brand by winning multiple awards at the esteemed Visual Grand Prix ( VGP ) 2025 in Japan , showcasing its dedication to innovation and excellence in audio technology . RICHMOND, BC , Nov. 27, 2024 /PRNewswire/ -- The Japanese VGP Awards, often dubbed the "Oscar in the Audio Industry," are the largest and most credible audio-visual honors in Asia , organized annually by Ongen Publishing Co. Ltd. since 1987. These awards aggregate evaluations from numerous countries, providing consumers with trustworthy guidance for their audio and visual purchases. Edifier's accolades at the VGP Awards underscore its significant contributions and innovation in the audio sector, solidifying its reputation as a leading brand in the industry. Stanley Wen , Edifier's CTO, expressed his pleasure upon receiving awards at the VGP 2025. "These awards provide the recognition that underscores Edifier's commitment to product development and its mission to provide high-quality, exceptional audio products to consumers. Edifier is humbled to be acknowledged yet again at the prestigious VGP awards. This is a reflection of our dedication to excellence in audio innovation." The Edifier M60 was a Special Prize Winner and Gold Award Winner. The M60 is a compact 2.0 desktop speaker optimized for high-resolution audio reproduction, making it an ideal enhancement for any desktop setup. Boasting a total output power of 66W (RMS), it delivers impressive sound quality through its 1" silk dome tweeter and 3" long-throw aluminium diaphragm mid-low drivers, all wrapped in a sleek design that complements modern aesthetics. The Comfo C (EDF200161) open-ear clip-on design earbuds were a Gold Award Winner. Each earbud features a three-axis sensor, allowing flexible use in either ear for added convenience. Weighing just 5.8 grams each, the design accommodates various ear shapes and sizes, ensuring a comfortable and secure fit for all users. Additionally, the 12mm dynamic driver with a titanium-coated composite diaphragm delivers dynamic, detailed, and powerful sound, enhancing the overall listening experience. Another Gold Award Winner was the W800BT Pro . The Edifier W800BT Pro headphones offer a premium listening experience with hybrid active noise cancelling technology and Hi-Res audio support. They feature AI call noise cancellation, and with an impressive 45 hours of playtime on a single charge and fast charging capabilities, these foldable over-ear headphones provide both convenience and comfort. Also recognized was the Edifier MR3 2.0 monitor speaker system which boasts Hi-Res audio certification and a flat frequency response ranging from 52Hz to 40kHz, delivering a robust 18W x 2 (RMS) total power output. With their advanced acoustic design, precise tuning, and high-quality craftsmanship, the MR3 speakers are an ideal choice for home studios, video editing, and everyday listening. The final Award Winner was the NeoDots True Wireless earbuds. The NeoDots integrate Hybrid driver units (BA and 10mm dynamic drivers), digital signal processing, and active crossover. This combination provides superior, balanced sound with high resolution and low distortion, achieving an impressive noise cancellation depth of up to -48dB. With Bluetooth V5.4 for enhanced connectivity, the NeoDots support multipoint connection, allowing seamless switching between music, videos, and calls across two devices simultaneously, making them a versatile choice for any user. The VGP awards celebrate outstanding products that significantly impact the industry with innovative technology and design, highlighting Edifier's ongoing development and expansion of its product offerings. With registered international trademarks in over 70 countries and a globally diverse workforce supported by distribution partners and resellers, Edifier continues to strengthen its presence in the audio market worldwide. About Edifier: Edifier specializes in premium sound systems that showcase technological innovation and design elegance, delivering outstanding audio experiences through a wide range of headphones, speakers, and music systems, for personal entertainment and professional excellence. Established in May 1996 in Beijing , Edifier is the brainchild of a small group of enterprising music lovers. Over the past 25 years, Edifier has been guided by the "passion for sound" principle, which helped the brand emerge as a world-class designer and manufacturer of award-winning sound systems. Today, Edifier serves audio lovers worldwide through its distributors in over 70 countries, with operations in North America , South America , Europe , the Middle East , and Asia Pacific . More information about Edifier is available online at www.edifier.com . View original content to download multimedia: https://www.prnewswire.com/news-releases/edifier-scoops-5-honours-at-prestigious-visual-grand-prix-2025-302317109.html SOURCE EdifierChimezie’s late layup lifts Boston University past Maine 59-56Cash handout plan is 'probably illegal'

European Cup News

European Cup video analysis

  • phmacao casino
  • 90jili cc casino login
  • lodibet 123
  • fortune gems apk
  • 90jili cc casino login