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Credit: Adobe Stock/ onephoto A study found schizophrenia and major depressive disorder (MDD) increase the risk of constipation , but the association with schizophrenia may only have limited clinical implications. 1 “Similar to previous studies, the risk of constipation was higher in participants with severe depression than in participants with mild depression,” wrote investigators, led by Jiali Liu, from the department of anorectal surgery at Affiliated Hospital of Nanjing University of Chinese Medicine, in People’s Republic of China. Constipation, although common, is one of the most difficult diseases to diagnose and treat. According to the American Gastroenterological Association, 16% of adults face constipation. This gastrointestinal disorder has a greater prevalence in older adults, females, certain medications, and mental diseases. Observational studies have shown the link between constipation and psychiatric disorders, namely anxiety and depression, but these studies did not examine the causal effects between the conditions. 2 Thus, investigators completed a Mendelian randomization analysis to assess whether constipation and psychiatric disorders—in this case, schizophrenia and MDD—had a causal relationship. 1 The study’s exposures were schizophrenia and MDD, and constipation was the outcome. The team recruited patients with schizophrenia (30,490 cases and 312,009 controls) and MDD (170,756 cases and 329,443 controls) from Psychiatric Genomics Consortium datasets of European ancestry. Constipation genetic data (17,246 cases and 201,546 controls) was obtained from The FinnGen summary statistics. Investigators used the inverse variance weighted (IVW) method to assess the causal relationship between schizophrenia and MDD with constipation. The LD score regression showed constipation was genetically correlated with schizophrenia and MDD (both P < .05). The Mendelian randomization analysis further demonstrated that schizophrenia (IVW odds ratio [OR], 1.05; 95% confidence interval [CI], 1.02 – 1.07; P < .01) and MDD (IVW OR, 1.21; 95% CI, 1.10 – 1.33; P < .01) were statistically significantly causally associated with the risk of constipation. Evidence of the causal relationship between constipation and psychiatric disorders was also shown with the MR Egger ratio (OR, 1.03; 95% CI, 0.93 – 1.16; P = .548 for schizophrenia; OR, 0.92; 95% CI, 0.48 – 1.76; P = .794 for MDD) and the weighted median odds ratio (OR, 1.05; 95% CI, 1.01 – 1.09; P < .01 for schizophrenia; OR, 1.19; 95% CI, 1.03 – 1.38; P = .02). “Bidirectional MR analysis revealed an obviously causal effect of depression on constipation, but no causal effect of constipation on depression,” investigators wrote. However, investigators noted that constipation could aggravate psychotic disorders, as patients with constipation were significantly more likely to experience depression, anxiety, somatization, and psychotic disorders. The Cohran’s Q report did not show heterogeneity among these inverse variances for both schizophrenia ( P = .11 > .05) and MDD ( P = .09 > .05). Investigators also observed no horizontal pleiotropy in the Egger intercept test for schizophrenia ( P = .81) and MDD ( P = .39). Despite schizophrenia having a statistically significant confidence interval of 1.02 – 1.07 ( P < .01), it fell within the Region of Bayesian analysis and the Practical Equivalence (ROPE), which defines an odds ratio range of 0.83 – 1.19 as a lack of clinical significance. “This suggested that the hypothesized pathophysiological links between [schizophrenia] and constipation conditions were not substantiated by our data, prompting a reevaluation of their clinical implications,” investigators wrote. Liu and colleagues said the study was limited by only examining the Psychiatric Genomics Consortium and FinnGen populations. Moreover, they added that they only examined schizophrenia and MDD due to the unavailable data on other psychiatric disorders and future studies should include other mental conditions. “In conclusion, we performed MR analysis concluding that there is suggestive evidence that [schizophrenia] and MDD potentially cause constipation,” investigators wrote. “However, [schizophrenia] and constipation, largely falling within the ROPE range, underscore a lack of clinical significance, and further confirmation is needed in conjunction with clinical studies.” References Liu J, Huang Y, Fu X, Wei J, Wei P. Associations of Schizophrenia and Major Depressive Disorder with Constipation: A Mendelian Randomization Study. Clin Exp Gastroenterol. 2024 Nov 26;17:349-357. doi: 10.2147/CEG.S485504. PMID: 39618883; PMCID: PMC11608058. Nellesen D, Chawla A, Oh DL, et al. Comorbidities in patients with irritable bowel syndrome with constipation or chronic idiopathic constipation: a review of the literature from the past decade. Postgrad Med. 2013;125:40–50. doi:10.3810/pgm.2013.03.2640

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TOMS RIVER, N.J. (AP) — A U.S. senator has called for mysterious drones spotted flying at night over sensitive areas in New Jersey and other parts of the Mid-Atlantic region to be “shot down, if necessary,” even as it remains unclear who owns the unmanned aircraft. “We should be doing some very urgent intelligence analysis and take them out of the skies, especially if they’re flying over airports or military bases,” Sen. Richard Blumenthal of Connecticut said Thursday, as concerns about the drones spread across Capitol Hill. People in the New York region are also concerned that the drones may be sharing airspace with commercial airlines, he said, demanding more transparency from the Biden administration. The White House said Thursday that a review of the reported sightings shows that many of them are actually manned aircraft being flown lawfully. White House National Security spokesman John Kirby said there were no reported sightings in any restricted airspace. He said the U.S. Coast Guard has not uncovered any foreign involvement from coastal vessels. “We have no evidence at this time that the reported drone sightings pose a national security or a public safety threat, or have a foreign nexus,” Kirby said, echoing statements from the Pentagon and New Jersey Gov. Phil Murphy. Pentagon spokesperson Sabrina Singh has said they are not U.S. military drones. In a joint statement issued Thursday afternoon, the FBI and the Department of Homeland Security said they and their federal partners, in close coordination with the New Jersey State Police, “continue to deploy personnel and technology to investigate this situation and confirm whether the reported drone flights are actually drones or are instead manned aircraft or otherwise inaccurate sightings.” The agencies said they have not corroborated any of the reported sightings with electronic detection, and that reviews of available images appear to show many of the reported drones are actually manned aircraft. “There are no reported or confirmed drone sightings in any restricted air space,” according to the statement. The drones appear to avoid detection by traditional methods such as helicopter and radio, according to a state lawmaker briefed Wednesday by the Department of Homeland Security. The number of sightings has increased in recent days, though officials say many of the objects seen may have been planes rather than drones. It’s also possible that a single drone has been reported more than once. The worry stems partly from the flying objects initially being spotted near the Picatinny Arsenal, a U.S. military research and manufacturing facility, and over President-elect Donald Trump’s golf course in Bedminster. In a post on the social media platform X, Assemblywoman Dawn Fantasia described the drones as up to 6 feet (1.8 meters) in diameter and sometimes traveling with their lights switched off. Drones are legal in New Jersey for recreational and commercial use but are subject to local and Federal Aviation Administration regulations and flight restrictions. Operators must be FAA certified. Most, but not all, of the drones spotted in New Jersey appeared to be larger than those typically used by hobbyists. Sen. Cory Booker of New Jersey said he was frustrated by the lack of transparency, saying it could help spread fear and misinformation. “We should know what’s going on over our skies,” he said Thursday. John Duesler, president of the Pennsylvania Drone Association, said witnesses may be confused about what they are seeing, especially in the dark, and noted it’s hard to know the size of the drones or how close they might be. “There are certainly big drones, such as agricultural drones, but typically they are not the type you see flying around in urban or suburban spaces,” Duesler said Thursday. Duesler said the drones — and those flying them — likely cannot evade detection. “They will leave a radio frequency footprint, they all leave a signature," he said. "We will find out what kind of drones they were, who was flying them and where they were flying them.” Fantasia, a Morris County Republican, was among several lawmakers who met with state police and Homeland Security officials to discuss the sightings from the New York City area across New Jersey and westward into parts of Pennsylvania, including over Philadelphia. It is unknown at this time whether the sightings are related. Duesler said the public wants to know what's going on. “I hope (the government agencies) will come out with more information about this to ease our fears. But this could just be the acts of rogue drone operators, it’s not an ‘invasion’ as some reports have called it,” Duesler said. “I am concerned about this it but not alarmed by it.” Associated Press reporters Mark Scolforo in Harrisburg, Pennsylvania; and reporter Darlene Superville and videojournalists Serkan Gurbuz and Nathan Ellgren in Washington, D.C., contributed to this report.From China Spring to Houston, family always at the root of Bell coaching tree

Emma Hayes insisted talk of which national anthem she would sing ahead of the USA’s 0-0 draw with England was “ridiculous” - and insisted the topic should not be used to “fuel a nationalist debate”. London-born Hayes returned to her native country as her US team earned a goalless friendly draw with England at Wembley in front of more than 78,000 fans on Saturday evening. Hayes, who left Chelsea in May after 12 years in charge, admitted to Standard Sport in an interview this week that it was going to “feel a bit weird” coaching her team against her own nation. Asked whether she sung the English national anthem as well as the American anthem ahead of kick-off, Hayes replied: “I was definitely mouthing the [English] national anthem. I was struggling with where to be in all of that. “I got to the end of the anthems, and I thought: it’s so ridiculous. I’m proud to be English, and I’m proud of our national anthems. I’ve sung it since I was a kid. “And I’m also proud to coach America and I’m proud of that national anthem. Two things are possible at once. I know we want to fuel a nationalist debate around it. The realities are: both countries are very dear to me for different reasons, and I’m proud to represent both of them.” Hayes said of the match: “It was two top teams. Sarina [Wiegman] is an amazing coach. I thought it was a tactical match-up. “I felt we should have done more for the volume for entries we had, but I thought we were the better team.”

Cars lined up at Fire Station #1 on Saturday to drop off toys and gifts in support of LIFE*SPIN. It was the annual London Emergency Services Lights & Sirens Toy Drive, where first responders collected items for families in need. “If you can believe, we’ve helped almost 1,500 families this Christmas season,” said Meagen Ciufo, LIFE*SPIN program coordinator. “We are always still in need of more toys so if people want to drop some off or reach out to us, the more toys, the merrier.” With Fire Fighter Santa greeting children, kids were given an opportunity to get up close to emergency service vehicles. Fire Fighter Santa bumps fists with a child at the annual London Emergency Services Lights & Sirens Toy Drive on Saturday Nov. 30, 2024 (Brent Lale/CTV News London) “It’s truly heartwarming to see our community come together, especially as we get to engage with families, let the kids experience the magic of emergency vehicles, and take a photo with Santa,” said Ciufo. “Every donation, no matter how big or small, makes a difference.” In partnership with LIFE*SPIN, the London Professional Fire Fighters Association (LPFFA) helped collect the toys. “This has become one of our most, privileged events to be involved in,” said Randy Evans, secretary with the LPFFA. “We've been doing a toy drive in some sense for the last 20 years, but really, on a small scale. About 15 years ago, we partnered with all the other first responders and LIFE*SPIN and we’re not just sponsoring a handful of families. We're looking after 1,200 to 1,400 families.” Volunteer Aaron Counsell helps unload a box of toys from a car during the annual London Emergency Services Lights & Sirens Toy Drive on Saturday Nov. 30, 2024 (Brent Lale/CTV News London) Ciufo said they are in need of some more volunteers over the next three weeks to help with making Christmas memorable for London families. “We’re always in need of new drivers to deliver the gifts to families,” said Ciufo. “People can do it in pairs. We get the route all ready, and they would just email us if they're interested in helping us deliver the toys for sure. Over the next little while we'll be packing for families. I think we still have about 800 families we have to pack for, so it's like Christmas village at our place. It's just packed with toys.” Shopping Trends The Shopping Trends team is independent of the journalists at CTV News. We may earn a commission when you use our links to shop. Read about us. Editor's Picks 20 Of The Best Gift Ideas For Men Under $200 13 Of The Best Self-Care Gifts You Can Find On Amazon Canada 19 Of The Best Tech Gifts Under $100 Home Our Guide To The Best Cookware Sets In Canada In 2024 (And Where To Get Them) Our Guide To The Best Space Heaters In Canada In 2024 (And Where To Get Them) Our Guide to the Best Portable Induction Cooktops in Canada in 2024 (And Where to Get Them) Gifts 21 Of The Best Gift Ideas For Women Under $300 19 Of The Best Stocking Stuffers For Teenagers 15 Useful Amazon Products That Make Great Stocking Stuffers Beauty Our Guide To The Best Self Tanners You Can Get In Canada 20 Anti-Aging Skincare Products That Reviewers Can’t Stop Talking About 12 Budget-Friendly Makeup Brushes And Tools Worth Adding To Your Kit Deals Here Are All The Best Amazon Black Friday Deals You Can Find On Beauty Products In Canada Here Are The Best Black Friday/Cyber Monday Deals You Can Find On Household Essentials In Canada This Smart Security Camera System Will Help You Keep An Eye On Your Home (And It's On Sale For 62% Off Right Now) London Top Stories 'We’ve helped 1,500 families this year': Lights and Sirens Toy Drive aids LIFE*SPIN Collision closes Wellington Road northbound London considers opening up more land for residential development in city’s rural areas Parts of region bracing for up to one metre of snow this weekend Sarnia to modify waste collection pickup - check to make sure your day hasn't changed London Knights win 17th straight, Cowan misses third straight game City and Byron property owner approach agreement after years of disputes CTV News London’s top stories from this week CTVNews.ca Top Stories Canadian team told Trump's tariffs unavoidable in short term in surprise Mar-a-Lago meeting During a surprise dinner at Mar-a-Lago, representatives of the federal government were told U.S. tariffs from the incoming Donald Trump administration cannot be avoided in the immediate term, two government sources tell CTV News. 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Poilievre suggests Trudeau is too weak to engage with Trump, Ford won't go there While federal Conservative Leader Pierre Poilievre has taken aim at Prime Minister Justin Trudeau this week, calling him too 'weak' to engage with U.S. president-elect Donald Trump, Ontario Premier Doug Ford declined to echo the characterization in an exclusive Canadian broadcast interview set to air this Sunday on CTV's Question Period. Bruce the tiny Vancouver parrot lands internet fame with abstract art Mononymous painter Bruce has carved a lucrative niche on social media with his abstract artworks, crafted entirely from the colourful juices of fruits. Why this Toronto man ran so a giant stickman could dance Colleagues would ask Duncan McCabe if he was training for a marathon, but, really, the 32-year-old accountant was committing multiple hours of his week, for 10 months, to stylistically run on the same few streets in Toronto's west end with absolutely no race in mind. It was all for the sake of creating a seconds-long animation of a dancing stickman for Strava. Mont-Tremblant World Cup skiing races cancelled due to warm weather Fans hoping to see the world's top woman skiers compete next week in Mont-Tremblant, Que., are out of luck after the PwC Tremblant World Cup was cancelled due to warm weather. Kitchener SIU invokes mandate after OPP-involved shooting on Highway 401 in Cambridge Highway 401, through Kitchener, was brought to a standstill Friday due to an investigation by Ontario Provincial Police. Family of Guelph, Ont. man killed in B.C. crash pushing for case review The family of a Guelph, Ont. man who was killed in a car crash in British Columbia is pushing for a review of the case, after learning about the charge that a driver involved is now facing. Region of Waterloo considers reducing, and even cutting, some services to keep tax increase down The Region of Waterloo is considering reducing or eliminating some services in an effort to lower the potential 2025 tax increase. Barrie Snow closes portion of Highway 11 OPP have closed a segment of Highway 11 in South Muskoka due to unsafe driving conditions caused by weather. Muskoka declares significant weather event The District Municipality of Muskoka has declared a significant weather event in response to the snow that continues to fall in the region. Road closed for 'suspicious' structure fire Emergency crews tended to a structure fire in Tottenham Saturday morning that has been deemed suspicious. Windsor Habitat Windsor-Essex marks milestone as it adapts to growing housing crisis Habitat for Humanity Windsor-Essex is marking a major milestone for the number of homes it has built, repaired or restored over the past 30 years. Bright Lights Windsor opens its 2024 display with a splash The cold couldn't keep hundreds from attending Friday night's opening of Bright Lights Windsor. The annual tradition returns this year with several new features. Firearms offender arrested in Windsor after violating conditions of release Just a month after being released from jail on firearm related charges, a Windsor man has been arrested once more. Northern Ontario Saultites keep digging as the snow keeps falling Snowfall in Sault Ste. Marie seemed to be delayed this year, but the cruel joke by Mother Nature saw a single dump make up for weeks of fall-like weather. Canadian team told Trump's tariffs unavoidable in short term in surprise Mar-a-Lago meeting During a surprise dinner at Mar-a-Lago, representatives of the federal government were told U.S. tariffs from the incoming Donald Trump administration cannot be avoided in the immediate term, two government sources tell CTV News. Man fined $10K for abandoning homemade barge in Lake Nipissing A man from Lavigne, Ont., has been fined $10,000 for abandoning a homemade barge in Lake Nipissing. Sault Ste. Marie Saultites keep digging as the snow keeps falling Snowfall in Sault Ste. Marie seemed to be delayed this year, but the cruel joke by Mother Nature saw a single dump make up for weeks of fall-like weather. Two arrested following shooting on Manitoulin Island The Manitoulin detachment of the Ontario Provincial Police have two people in custody following a shooting incident in Wikwemikong Unceded Territory on Thursday. Another 60 cm of snow possible in the Sault as severe weather continues Closures and cancellations are piling up in Sault Ste. Marie as a major winter storm continues for another day Friday. Ottawa New plan in the making to free cargo ship stuck in St. Lawrence River A new plan to free the Tim S. Dool, a large cargo ship that ran aground on a shoal along the St. Lawrence River near Morrisburg, Ont. last week is expected to be finalized early next week. Here's a look at the latest holiday movies this season This holiday season has a special edition at the theatres with movies "that everyone has been waiting for," says a movie expert from Ottawa. What's happening in Ottawa this weekend: Nov.29-Dec. 1 Santa Claus visits Ottawa and eastern Ontario, the Ottawa Black Bears play their first game and Christmas market season continues. CTVNewsOttawa.ca looks at things to do in Ottawa and eastern Ontario this weekend. Toronto Toronto man accused of posing as surgeon, performing cosmetic procedures on several women A 29-year-old Toronto man has been charged after allegedly posing as a surgeon and providing cosmetic procedures on several women. Why this Toronto man ran so a giant stickman could dance Colleagues would ask Duncan McCabe if he was training for a marathon, but, really, the 32-year-old accountant was committing multiple hours of his week, for 10 months, to stylistically run on the same few streets in Toronto's west end with absolutely no race in mind. It was all for the sake of creating a seconds-long animation of a dancing stickman for Strava. 'A huge, huge hit:' Ontario would be disproportionately impacted by Trump’s proposed tariffs, expert says If U.S. President-elect Donald Trump follows through on a threat to impose a 25 per cent tariff on all Canadian imports, Ontario will likely see the brunt of the impact, a business professor at Carleton University says. Montreal Buying a home? Here's everything you need to know about Quebec's 'welcome' tax Anyone who has bought a home in Quebec knows the rollercoaster high of making that big, life-changing purchase – and the sudden crash that occurs when the welcome tax bill comes in the mail, alongside its 30-day payment deadline. Immigrants take to the streets to protest against the freezing of immigration programmes In response to the freeze on immigration programmes announced by Ottawa, an organization that defends the rights of immigrants is organising a demonstration in front of the Montreal office of the Quebec Ministry of Immigration, Francisation and Integration early on Saturday afternoon. Montreal researchers make breakthrough discovery in fighting HIV Researchers in Montreal have made a breakthrough discovery in HIV research by finding a way to expel the virus from its hiding places and destroy it. Atlantic Furry fashionista’s turn Halifax street into Maritimes’ cutest runway The annual pet parade, an adored holiday tradition, returned to Halifax on Saturday. 3,500 people without power in New Brunswick after heavy snowfall Roughly 3,500 people in New Brunswick are still without power after wet, heavy snowfall caused trees to come into contact with power lines early Friday morning. Man charged after Halifax high school placed in hold and secure A man has been charged after a high school in Halifax was placed in hold and secure Friday morning. Winnipeg City shuts out province with 6-0 win in Winnipeg 150 hockey game The provincial government opened the floodgates to the City of Winnipeg Saturday, falling 6-0 in a match-up 50 years in the making. True North officially buys Portage Place Mall True North Real Estate Development (TNRED) has officially purchased Portage Place Mall. Canopy skating rink opens at The Forks Winnipeggers looking to lace up their skates this season can head to The Forks and hit the ice at the canopy rink. Calgary Man who died trying to help stranded motorist identified as Khalid Farooq, father of 5 The man who lost his life trying to help a stranded motorist Wednesday has been identified as Khalid Farooq. Cautious optimism? Alberta energy sector prepping for a turbulent 2025 Energy sector leaders say they're happy with how 2024 went but fear the stretch of good fortune could end in 2025. Canadian team told Trump's tariffs unavoidable in short term in surprise Mar-a-Lago meeting During a surprise dinner at Mar-a-Lago, representatives of the federal government were told U.S. tariffs from the incoming Donald Trump administration cannot be avoided in the immediate term, two government sources tell CTV News. Edmonton Canadian team told Trump's tariffs unavoidable in short term in surprise Mar-a-Lago meeting During a surprise dinner at Mar-a-Lago, representatives of the federal government were told U.S. tariffs from the incoming Donald Trump administration cannot be avoided in the immediate term, two government sources tell CTV News. Massage therapist charged in connection with sexual assault at Mill Woods clinic An Edmonton massage therapist has been charged with sexual assault in connection with an incident earlier this year. Ryan Nugent-Hopkins scores in OT to lift Oilers to 4-3 win over Utah Ryan Nugent-Hopkins scored 1:18 into overtime and the Edmonton Oilers beat the Utah Hockey Club 4-3 on Friday night. Regina Regina's LED volume wall leaving Sask. months after opening Less than a year after an LED volume wall was introduced to the film world in Saskatchewan, the equipment is making its exit from the province. Over 400 volunteers play a part in 2024 Canadian Western Agribition As the Canadian Western Agribition (CWA) comes to s close, organizers are celebrating the volunteers who have helped make the event a success over the years. Postal workers union files unfair labour practice complaint over Canada Post layoffs The union representing Canada Post workers has filed an unfair labour practice complaint with the Canada Industrial Relations Board over the layoffs of striking employees. Saskatoon Saskatoon priest accused of sexual assault says he meant to encourage young girl with hug and kiss A Saskatoon priest accused of sexual assault says he meant to encourage and reassure a young girl when he hugged and kissed during his testimony at Saskatoon Provincial Court Friday. One dead, two injured in Sask. highway collision A 61-year-old man was killed and two others were taken to hospital following a collision between an SUV and a truck near Prince Albert on Friday night. Saskatoon temporary smudge location to be taken down While the City of Saskatoon says it granted a temporary permit for smudging and a ceremonial open fire, that expired at 6p.m. Tuesday night. Vancouver 1 dead following crash on Sea to Sky Highway Bruce the tiny Vancouver parrot lands internet fame with abstract art Mononymous painter Bruce has carved a lucrative niche on social media with his abstract artworks, crafted entirely from the colourful juices of fruits. Canadian team told Trump's tariffs unavoidable in short term in surprise Mar-a-Lago meeting During a surprise dinner at Mar-a-Lago, representatives of the federal government were told U.S. tariffs from the incoming Donald Trump administration cannot be avoided in the immediate term, two government sources tell CTV News. Vancouver Island Yuletide festivities help kick off holiday season in Greater Victoria Greater Victoria has a host of yuletide festivities this weekend for residents ready to kick off the holiday season. Supreme Court clears way for B.C. to include other governments in opioid lawsuit B.C. Attorney General Niki Sharma says a Supreme Court of Canada victory has cleared a "pathway" for governments across the country to go after opioid makers and distributors for damages arising from the opioid crisis. Study of 2023 Okanagan wildfires recommends limiting development in high-risk areas A study into the devastating wildfires that struck British Columbia's Okanagan region in 2023 has recommended that government and industry limit development in high-fire-risk areas. Stay ConnectedA man tragically died after collapsing on a night out in Louth. Emergency services were at the scene of the bar where he collapsed within seven minutes on Saturday evening, according to the owner. Lincolnshire Police confirmed the man sadly died in hospital. The tragedy happened in The King's Head, in Mercer Row. A spokesperson for Lincolnshire Police said: "We can confirm that a man in his twenties was taken ill at The King’s Head on Mercer Row in Louth during the evening of Saturday 21 December, and he sadly died in hospital. "The file has been passed to the coroner. There are believed to be no suspicious circumstances." The owner of the King's Head, Sharon Davies, said: "It is shocking for everyone. It is so horrific and sad. It is his family and friends that we are thinking of the most." Sharon, who has owned the hotel and bar for 21 years, said: "In all my time, I have never experienced anything like that. We closed straight away." She was in charge on Saturday evening. "As soon as staff were made aware, they did CPR. We called 999 and his friends were calling the ambulance too. Someone went to get the defibrillator from outside the Market Hall in New Street and the paramedics were here within seven minutes, which was amazing," she said. The owner told how staff had greeted the group of friends earlier in the evening and all were polite and friendly and sat together near the bar. She told how staff ushered members of the public out of a separate door after the man collapsed, while emergency services rushed in through the front door. Ambulances were parked on Mercer Row. East Midlands Ambulance First Responders arrived and, moments later, two double-crewed ambulances arrived. Sharon said: "They were all brilliant. They were here within seven to eight minutes and they tried to revive him for about three-quarters of an hour. My son Chris helped everyone to leave. We were full with guests having meals. "It was a busy night before Christmas. I made sure all the staff were okay and spoke to the parents of some of them when they came to collect them. Some have had time off. "It is so, so sad. I feel devastated for his family. I have kids as well. You never expect when they go out for a night out that you won't see them again. It is horrific and sad." Sharon added: "I am so proud of my staff. But we wish it had never happened." Keep up to date with all the latest breaking news and top stories from Grimsby with our free newsletter

AP Sports SummaryBrief at 3:39 p.m. ESTREDWOOD CITY, Calif., Dec. 02, 2024 (GLOBE NEWSWIRE) -- Biomea Fusion, Inc. (Nasdaq: BMEA) (“Biomea” or the “Company”), a clinical stage biopharmaceutical company focused on the discovery and development of oral covalent small molecules to treat and improve the lives of patients with diabetes, obesity, and genetically defined cancers, today announced that on December 2, 2024, the compensation committee of Biomea’s board of directors granted one new employee non-qualified stock options to purchase an aggregate of 30,000 shares of the Company’s common stock. The shares underlying the employee’s stock options will vest 1/16 on a quarterly basis over four years, subject to the employee’s continued employment with the Company on such vesting dates. The above-described award was made under Biomea’s 2023 Inducement Equity Plan (the “Plan”). The above-described award was granted as an inducement material to the employee entering into employment with the Company in accordance with Nasdaq Listing Rule 5635(c)(4) and was granted pursuant to the terms of the Plan. The Plan was adopted by Biomea’s board of directors on November 17, 2023. About Biomea Fusion Biomea Fusion is a clinical-stage biopharmaceutical company focused on the discovery and development of oral covalent small molecules to improve the lives of patients with diabetes, obesity, and genetically defined cancers. A covalent small molecule is a synthetic compound that forms a permanent bond to its target protein and offers a number of potential advantages over conventional non-covalent drugs, including greater target selectivity, lower drug exposure, and the ability to drive a deeper, more durable response. We are utilizing our proprietary FUSIONTM System to discover, design and develop a pipeline of next-generation covalent-binding small-molecule medicines designed to maximize clinical benefit for patients. We aim to have an outsized impact on the treatment of disease for the patients we serve. We aim to cure. Visit us at biomeafusion.com and follow us on LinkedIn , X and Facebook . Contact: Investor & Media Relations Ramses Erdtmann re@biomeafusion.com

The morning catch up: Aussie shares to rally, US markets respond to the first tariff announcements

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The Gwent Bridge Academy, one of Newport's longest-standing social clubs, held its annual President's Day event on October 27. This was a particularly special occasion for the club as it marked 50 years since the club was founded in Newport by the late Barry Clowes. Guests of honour at the celebrations included the Mayor of Newport, Ray Mogford, and his wife Sallie, as well as both of Newport's local MPs Jessica Morden and Ruth Jones. The club chairperson Enid Snelgrove gave a speech telling the history of the club, which was originally founded by Barry as a fee-paying academy for advancing the game of bridge. Sophie Cunningham then told the moving story of how her father Graham Jones inherited the Academy on the death of Barry Clowes, turned it into a members club and moved it into the premises on Clayton Street where it remains to this day. Enid spoke about the effect that Covid has had on the club, and how the club is adapting by moving online. Both Jessica Morden and Ray Mogford also spoke about the importance to Newport of institutions such as the Academy, and looked forwards to a bright future for the club. On that note, Bill Parkinson, the club secretary was keen to let people know that the club is looking for new players and is running lessons. "Bridge is a fantastic way to keep your mind sharp, meet new people, and have fun. We'd encourage anyone with an interest in learning bridge or enhancing their skills to come to our lessons," Bill said. The guests enjoyed a delicious buffet lunch provided by local Usk caterers Napier Catering, then moved on to the main event of the day - the bridge tournament. More than 60 players competed for three hours for the President's Cup. This was won by Paul Cunningham and Joseph Bentley. The club runs bridge lessons on Tuesday nights and new members are always welcome.Texas vs. Texas A&M live score, updates, highlights from 2024 college football rivalry game | Sporting News

Hamas, the Iran-backed Palestinian terrorist group, released a video Saturday of one of the four surviving American hostages, Edan Alexander, in which he is shown appealing to “President Trump” to pressure Israel for his release. Alexander is one of four living U.S. citizens still being held as hostages by Hamas (several others are still classified as hostages but are believed to be dead). A fifth, Hersh Goldberg-Polin, was executed by Hamas in August. The video is the first sign that Alexander is still alive, and is therefore being treated in Israel as an important and valuable piece of evidence, aside from its problematic content. The evident intent by Hamas is to pressure Trump in the same way that it sought to pressure President Joe Biden, using the plight of the hostages to cause the U.S. to lean on the Israeli government to give up the fight in Gaza. Hamas has refused any hostage deal that does not involve Israel giving up on its mission of destroying the group. In the video, recorded under duress, Alexander is shown in a state of emotional distress, crying at times and holding his head in his hands. He emphasizes that his life is in danger, and alludes to “new instructions” by Hamas, ordering hostages to be murdered if the Israel Defense Forces (IDF) tries to rescue them. In addition to blaming Israeli Prime Minister Benjamin Netanyahu for the failure to prevent the October 7 attack, Alexander is shown urging Israelis to attend demonstrations against the government, and suggests that Hamas is rejecting Netanyahu’s recent offer to pay $5 million to any Palestinian who returns an Israeli hostage alive. In addition to messages in Hebrew, directed to Israelis and to his family, Alexander is shown saying, in English: My name is Edan Alexander. I am an American-Israel citizen currently being held captive in the Gaza Strip. As an American, I have always believed in the power of the United States. And now I am sending my message. Please, use your influence and the full power of the United States to negotiate for our freedom. Every day here feels like an eternity, and the pain from inside grows, day-to-day. Please do not make the mistake Biden has been doing. The weapons he has sent are now killing us. And the unlawful sieges [sic] are now starving [us]. I don’t want to end up dead, like my fellow citizen, Hersh [Goldberg-Polin]. Hamas tried the same tactics with President Biden — with some success, as the Biden-Harris administration withheld critical weapons and machinery needed by Israel for the fight against Hamas in Gaza and Hezbollah in Lebanon. Trump promised at the Republican National Convention in Milwaukee in July that those holding American hostages would “be paying a very big price” if they did not return those hostages before he took office in January 2025. Joel B. Pollak is Senior Editor-at-Large at Breitbart News and the host of Breitbart News Sunday on Sirius XM Patriot on Sunday evenings from 7 p.m. to 10 p.m. ET (4 p.m. to 7 p.m. PT). He is the author of The Agenda: What Trump Should Do in His First 100 Days , available for pre-order on Amazon. He is also the author of The Trumpian Virtues: The Lessons and Legacy of Donald Trump’s Presidency , now available on Audible. He is a winner of the 2018 Robert Novak Journalism Alumni Fellowship. Follow him on Twitter at @joelpollak .